Medical News Today, 5/18/2011
Mast cells, known for their role in allergies and anaphylaxis, have also been shown to mediate inflammation in the bladders of patients with interstitial cystitis/painful bladder syndrome (IC/PBS).
Researchers from the United Kingdom explored the possibility that honey, known for its benefits in wound healing, cytokine interaction and anti-oxidant effects, could have an effect on mast-cell degranulation in patients with IC/PBS if used intravesically.
Authors measured spontaneous calcium ionophore A23187 and A23187-induced histamine release on cells from the LAD2 mast cell line, comparing the effects of a range of medicinal honeys to those of control preparations (including a clover nectar, sugar syrup and agents typically used to treat IC/PBS.
The honeys inhibited spontaneous and A23187-induced histamine release significantly better than the control preparations (ranging from 60 percent to 100 percent, compared to 40 percent inhibition with sugar syrup, 36 percent for clover nectar and a maximum inhibition of 24 percent with either drug at either dilution), suggesting that honey, delivered intravesically, may provide some level of success to patients suffering with IC/PBS.
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