Propolis Standardized Extract (EPP-AF®), an Innovative
Chemically and Biologically Reproducible Pharmaceutical Compound for Treating
Wounds
Int J Biol Sci 2012; 8(4):512-521
The aim of this study was to develop a formulation,
containing the propolis standardized extract (EPP-AF®), which can assist in the
healing of skin lesions.
To achieve this objective the antimicrobial activity and
chemical composition of the propolis extract was determined. The final product
was subjected to in vitro and in vivo pre-clinical evaluation. The broth
macrodilution method was used to determine the antimicrobial activity of the
extracts and formulations against the microorganisms most commonly found in
burns, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli,
Staphylococcus aureus and Staphylococcus epidermidis.
Wistar rats with puncture wounded skin were used to evaluate
the wound healing properties of propolis. The results of chemical and
biological characterization demonstrated the batch-to-batch reproducibility of
the standardized extract which is an unprecedented result.
The antimicrobial and wound healing activity of the
pharmaceutical studied showed the best results when samples contain 3.6%
propolis, suggesting that this is the most promising composition.
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