Effect of Topical Application of Different Substances on Fibroplasia
in Cutaneous Surgical Wounds
ISRN Dermatol, 2012;2012:282973
Background. Fibroblasts on the edges of a surgical wound are
induced to synthesize collagen during the healing process which is known as
fibroplasia.
Objective. The aim of this study was to determine the effect
of the application of different substances on fibroplasia of cutaneous surgical
wounds on rats.
Materials and Methods. 48 Wistar rats were divided into
three groups. A surgical wound 1 cm in diameter and 1 mm in depth was created
on the dorsum of each animal. The surgical wounds were submitted to the topical
application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001%
dexamethasone in a cream base every 12 hours. The animals were sacrificed
three, seven, 14, and 28 days postoperatively. The specimens were histologically
processed and stained with Masson's trichrome. The assessment of fibroplasia
was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26
to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than
75% collagen deposition.
Results. There were statistically significant differences in
collagen deposition between the substances at all postoperative evaluation
times.
Conclusion. Propolis and alcohol promoted greater collagen
deposition in surgical wounds than dexamethasone.
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