The Anticancer Mechanism of Caffeic Acid Phenethyl Ester (CAPE): Review of Melanomas, Lung and Prostate Cancers
Eur Rev Med Pharmacol Sci, 2012 Dec;16(15):2064-8
BACKGROUND: Caffeic acid phenethyl ester (CAPE), an active
component of propolis extract, specifically inhibits NF-κB. It exhibits
antioxidant, antiinflammatory, antiproliferative, cytostatic, and most
improtantly, antineoplastic properties.
AIM: The aim of the present mini-review is to summarize and
evaluate the anticancer mechanism of CAPE with examples of several cancer
types.
RESULTS: In view of the mechanisms and findings in our
laboratory and those of others in literature, we suggest that CAPE possess
anticancer and apoptosis inducing activities.
CONCLUSIONS: Further researches are needed regarding the
anticancer basis of CAPE in all disciplines of medicine. Also, clinical potential
toxicities of CAPE should be revealed if it is going to be used as an
anticancer agent.
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