Evid Based Complement Alternat Med, 2013;2013:879845
Cisplatin is used as a potent anticancer drug, but it often
causes nephrotoxicity. Bee venom (BV) has been used for the treatment of
various inflammatory diseases, and its renoprotective action was shown in NZB/W
mice. However, little is known about whether BV has beneficial effects on
cisplatin-induced nephrotoxicity and how such effects might be mediated. In the
present study, the BV-injected group showed a significant increase in the
population of Tregs in spleen. Although there was no significant difference in
the numbers of Tregs 3 days after cisplatin injection between the BV- and
PBS-injected groups, more migration of Tregs into the kidney was observed 6
hours after cisplatin administration in BV group than in PBS group. In
addition, BV-injected mice showed reduced levels of serum creatinine, blood
urea nitrogen, renal tissue damage, proinflammatory cytokines, and macrophage
infiltration into the kidney 3 days after cisplatin administration. These
renoprotective effects were abolished by the depletion of Tregs. The anticancer
effect of repeated administrations of cisplatin was not affected by BV injection.
These results suggest that BV has protective effects on
cisplatin-induced nephrotoxicity in mice, at least in part, through the
regulation of Tregs without a big influence on the antitumor effects of
cisplatin.
No comments:
Post a Comment