Integrated Analysis of COX-2 and iNOS Derived Inflammatory
Mediators in LPS-Stimulated RAW Macrophages Pre-Exposed to Echium plantagineum
L. Bee Pollen Extract
PLoS One, 2013;8(3):e59131
Oxidative stress and inflammation play important roles in
disease development. This study intended to evaluate the anti-inflammatory and
antioxidant potential of Echium plantagineum L. bee pollen to support its
claimed health beneficial effects.
The hydromethanol extract efficiently scavenged nitric oxide
((•)NO) although against superoxide (O2 (•-)) it behaved as antioxidant at
lower concentrations and as pro-oxidant at higher concentrations. The
anti-inflammatory potential was evaluated in LPS-stimulated macrophages. The
levels of (•)NO and L-citrulline decreased for all extract concentrations
tested, while the levels of prostaglandins, their metabolites and isoprostanes,
evaluated by UPLC-MS, decreased with low extract concentrations.
So, E. plantagineum bee pollen extract can exert
anti-inflammatory activity by reducing (•)NO and prostaglandins. The extract is
able to scavenge the reactive species (•)NO and O2 (•-) and reduce markers of
oxidative stress in cells at low concentrations.
NOTE: Echium plantagineum contains pyrrolizidine alkaloids
and is poisonous.
1 comment:
There is so much to bees and their honey.
I have also found some good beekeeping comedy if you are looking for some light relief.
Post a Comment