Bees' Honey Attenuation of Metanil-Yellow-Induced
Hepatotoxicity in Rats
Evid Based Complement Alternat Med, 2013;2013:614580
The present study aims to investigate the protective effect
of bees' honey against metanil-yellow-induced hepatotoxicity in rats.
Rats were divided into 7 groups: control group; three groups
treated with 50, 100, and 200 mg/kg metanil yellow, and three groups treated
with metanil yellow plus 2.5 mg · kg(-1) · day(-1) bees' honey for 8 weeks. The
obtained data showed that the antioxidant/anti-inflammatory activity of bees'
honey reduced the oxidative stress in the liver tissue and downregulated the
inflammatory markers. In addition, the elevated levels of AGE and the activated
NF- κ B in the metanil-yellow-treated animals were significantly attenuated.
Moreover, the levels of TNF- α and IL-1 β were significantly attenuated as a
result of bees' honey administration. Furthermore, the histopathological
examination of the liver showed that bees' honey reduced fatty degeneration,
cytoplasmic vacuolization, and necrosis in metanil-yellow-treated rats.
In conclusion, the obtained data suggest that bees' honey
has hepatoprotective effect on acute liver injuries induced by metanil-yellow
in vivo, and the results suggested that the effect of bees' honey against
metanil yellow-induced liver damage is related to its
antioxidant/anti-inflammatory properties which attenuate the activation of NF-
κ B and its controlled genes like TNF- α and IL-1 β .
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