Antifungal Activity of Iranian Honeybees Against Candida,
Aspergillus Species and Trichophyton Rubrum
Journal of Food Processing and Preservation, Nov. 18, 2013
Due to limited available antifungal agents, searching for
new antifungal agents stimulated research on new chemotherapeutic agents in
natural products. The current study was carried out to assess the antifungal
activity of different Iranian honeys with different botanical origin against
some important fungi, such as azoles-resistant Candida species. Seven types of
honey samples including Thymus vulgaris, Alfalfa, Citrus, Zizyphus, Astragalus,
Chamaemelum nobile and multiflora honey were collected. Minimum inhibitory
concentrations microdilution broth method was used for assessing antifungal
activity of honeys. The results revealed variations in the antifungal activity
of the examined honey samples. Alfalfa and Thymus honeys were significantly
more effective than other honeys and Zizyphus and Chamaemelum honeys exhibited
lowest antifungal activity. Trichophyton rubrum and C. krusei had the highest
and lowest sensitivity to the honey's antifungal activity among fungal species,
respectively. No statistically significant differences in susceptibility to
honey samples were determined among fluconazole resistance and susceptible
Candida species.
Practical Applications
In the present study, the antifungal properties of honeys
with different botanical origin against pathogenic fungal species were
examined. Furthermore, the inhibitory properties of the honeys against fungal
strains resistant to existing antifungal drugs were assessed. Antimicrobial
properties of plants which were the origin of honeys in this study were also
investigated. Results showed a direct correlation between the type of nectar
for honeys and antifungal properties. More importantly, inhibitory effects of
honeys against several fungal species and Trichophyton rubrum, particularly
resistant Candida species was shown. It seems that appropriate concentrations
of honey can be used for controlling and treating of dermatophytosis and
dermatomycosis.
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