BACKGROUND:
Propolis and curcumin have antioxidant, anti-inflammatory,
immunomodulatory, and neuroprotective features. The goal of this study was to
determine the effects of propolis and curcumin on nerve healing in rat sciatic
nerve crush injuries and to compare these effects with results obtained using
steroid treatment.
METHODS:
In the sham group, the right sciatic nerves of rats were
dissected and exposed, and the skin was closed without any additional
manipulation. In the control group (group C), after the right sciatic nerves of
rats were exposed, crush damage was inflicted using a surgical clamp. In the
control-methylprednisolone group, crush injuries were inflicted on sciatic
nerves as in group C. After injury, 1-mg/kg methylprednisolone was administered
daily for 6 days and was then tapered for 4 days. In the curcumin group, crush
injuries were inflicted on sciatic nerves as in group C. Then, 100-mg/kg
curcumin was given every day. In the propolis group, crush injuries were
inflicted on sciatic nerves as in group C. Then, 200-mg/kg propolis was given
every day. Rats were evaluated after 28 days using functional (walking track
analysis and electrophysiological measurements), histomorphometric, electron
microscopic, and muscle weight measurements.
RESULTS:
Compared to the control groups, the curcumin and propolis
groups had better functional (walking track analysis and electrophysiological)
results after experimental peripheral nerve crush injury.
CONCLUSIONS:
Curcumin and propolis, 2 traditional drugs, had a positive
effect on nerve crush injuries. We are convinced that they can be used to
support routine treatment in such nerve injuries.
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