Efficacy of honey in comparison to topical corticosteroid
for treatment of recurrent minor aphthous ulceration: A randomized, blind,
controlled, parallel, double-center clinical trial
Quintessence Int, 2014 Jul 10
Background: Recurrent aphthous ulceration represents a very
common mucosal disorder that general dentists may encounter on a daily basis,
and for which there is no curative treatment. The best treatment that can be
achieved is to avoid local traumatic precipitants, lessen the pain and duration
of ulceration by suppressing the local immune response, and prevent secondary
infection.
Objective: The objective of this study was to clinically
determine the efficacy of honey as a topical treatment of recurrent minor
aphthous ulceration in a Saudi cohort.
Method and Materials: A randomized, blind, controlled,
parallel, double-center clinical trial was carried out. Honey was applied by
patients four times a day for 5 days. Clinical parameters (ulcer size, pain
scale, and degree of erythema and healing) were recorded both at baseline and
during the follow-up period.
Results: There were 94 subjects, with 180 minor recurrent
aphthous ulcerations. The ulcers were distributed as 67, 57, and 56 ulcers for
honey, topical corticosteroid, and Orabase treatment, respectively. There was a
statistically significant difference between the honey group and the other two
groups in terms of reduction of ulcer size, days of pain, and degree of
erythema. No side effects were reported in any group.
Conclusion: Honey was found to be effective and safe in
reducing minor aphthous ulcer pain, size, and erythema in a Saudi cohort.
No comments:
Post a Comment