Toxins 2016, 8(11), 315
Venoms, especially bee venom, have been used since ancient times as a healing treatment for various disorders. The therapeutic value of honey bee venom to improve the quality of life of patients has been acknowledged for over a hundred years.
Modern approaches of venomics have allowed for the discovery of venom constituents that have proven to be of pharmacological significance and have opened the way to optimization of therapeutic strategies through the use of active components such as melittin and apamin. Subsequently, the application scope of honey bee venom has been expanding from conventional antinociceptive effect to degenerative diseases of the nervous system. This seems to be due to the properties of venom enzymes and peptides for their natural stability as injectable solutes, their effectiveness in reaching targeted tissues, and their ability to synergize their actions by enhancing cell–cell interactions.
Expansion of the therapeutic application of bee and wasp venoms has advanced particularly far in recent years, so this is an opportune time to present this Special Issue on bee and wasp venoms, their biological characteristics and therapeutic application.