Bee Venom Injection Produces a Peripheral Anti-Inflammatory Effect by Activation of a Nitric Oxide-Dependent Spinocoeruleus PathwayNeurosci Lett. 2007 Nov 5
Our recent data, obtained using a zymosan-induced inflammatory air pouch model in mice, have demonstrated that subcutaneous bee venom (BV) injection into the hind limb selectively activates the contralateral brain stem locus coeruleus (LC) and then via a descending noradrenergic pathway and subsequent adrenal medullary catecholamine release induces a potent anti-inflammatory effect...
Collectively these results indicate that spinal NO generated from inducible NOS is involved in the BV-induced LC activation that underlies BVAI.
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