NF-kappaB-Activated Tissue Transglutaminase is Involved in Ethanol-Induced Hepatic Injury and the Possible Role of Propolis in Preventing FibrogenesisToxicology, 2008 Apr 18;246(2-3):148-57
The increased expression and cross-linking activity of tissue transglutaminase (tTG) have been demonstrated in acute liver injury and fibrosis. We focused on the molecular mechanisms that contribute to ethanol-induced tTG expression and investigated the efficacy of propolis components in preventing both the tTG expression in vitro and fibrogenesis in vivo…
We also found that administration of pinocembrin (PIN), one of the major components of propolis, inhibited tTG activation and significantly prevented the development of thioacetamide (TAA)-induced liver cirrhosis…
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