Evidence that the Anticarcinogenic Effect of Caffeic Acid Phenethyl Ester in the Resistant Hepatocyte Model Involves Modifications of Cytochrome P450Toxicological Sciences, April 7, 2008
Abstract: Caffeic acid phenethyl ester (CAPE), a natural component of propolis, shows anti-carcinogenic properties in the modified resistant hepatocyte model when administered before initiation or promotion of hepatocarcinogenesis process; however, information about the mechanism underlying this chemoprotection is limited.
The aim of this work was to characterize the effect of CAPE on cytochrome P450 (CYP), which is involved in diethylnitrosamine (DEN) metabolism during the initiation stage of chemical hepatocarcinogenesis…
Our results suggest that CAPE modifies the enzymatic activity of cytochrome P450 isoforms involved in the activation of DEN, such as CYP1A1/2, 2B1/2. These findings describe an alternative mechanism for understanding the ability of CAPE to protect against chemical hepatocarcinogenesis.
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