Saturday, March 14, 2009

New Compound Isolated from Royal Jelly

Isolation of (E)-9,10-Dihydroxy-2-Decenoic Acid from Royal Jelly and Determination of the Absolute Configuration by Chemical Synthesis
Tetrahedron: Asymmetry, Article in Press

(E)-9,10-Dihydroxy-2-decenoic acid 1 was isolated as a new compound from royal jelly. The planar structure was deduced by spectroscopic analyses, whereas the absolute configuration was established by chemical synthesis of both enantiomers of 1.

The natural product was revealed to be ca. 3.5:1 mixture of (R)- and (S)-acids by comparison of 1 with authentic samples.

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