Caffeic Acid Phenethyl Ester, an Active Component of Honeybee Propolis Attenuates Osteoclastogenesis and Bone Resorption via the Suppression of RANKL-Induced NF-kappaB and NFAT Activity
J Cell Physiol, 2009 Dec;221(3):642-9
Receptor activator NF-kappaB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acid phenethyl ester (CAPE), a natural NF-kappaB inhibitor from honeybee propolis has been shown to have anti-tumor and anti-inflammatory properties.
In this study, we investigated the effect of CAPE on the regulation of RANKL-induced osteoclastogenesis, bone resorption and signaling pathways…
Taken together, our findings demonstrate that inhibition of NF-kappaB and NFAT activation by CAPE results in the attenuation of osteoclastogenesis and bone resorption, implying that CAPE is a potential treatment for osteolytic bone diseases.