Effect of Brazilian propolis on Sneezing and Nasal Rubbing in Experimental Allergic Rhinitis of Mice
Immunopharmacol Immunotoxicol, 2009;31(4):688-93
We studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice.
A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose.
Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg.
On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml.
These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.