Immunostimulant Effect of Egyptian Propolis in Rabbits
Scientific World Journal, May 2, 2012
The present experiment was conducted to study the effect of
ethanolic extract of Egyptian propolis given alone or in combination with
inactivated Pasteurella multocida vaccine on rabbits challenged with a virulent
strain of Pasteurella multocida.
Fifty-six New-Zealand rabbits, 6-8 weeks old and
non-vaccinated against pasteurellosis, were randomly divided into eight equal
groups. The first group was kept as a control for the experiment. The other
groups received different treatments with propolis extract, inactivated
vaccine, or both. The experiment continued for seven weeks during which
clinical signs, body weight, and mortality rate were monitored, and blood
samples were collected weekly for evaluating the leukogram, serum biochemistry,
and immune response in all groups of animals.
At the end of the seventh week, the animals were subjected
to challenge with a virulent strain of Pasteurella multocida. Two weeks later,
tissue specimens were collected from different organs for histopathological
examination.
Results showed that rabbits of the groups treated with both
propolis and the vaccine by different routes appeared healthy after challenge.
It has been concluded that alcoholic extract of propolis administrated in
combination with inactivated Pasteurella multocida vaccine has no adverse
effects on the general health conditions and enhances immune response in
rabbits.
No comments:
Post a Comment