J Pharmacol Sci, 2013 Feb 19;121(2):110-8
Oral mucositis induced by chemotherapy or radiotherapy has
an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes
considerable morbidity. We evaluated the effect of royal jelly (RJ) on
5-fluorouracil (5-FU)-induced oral mucositis in hamsters.
Oral mucositis was
induced in hamsters through a combination of 5-FU treatment and mild abrasion
of the cheek pouch. RJ was contained in chitosan-sodium alginate film (RJ
film). Films were attached to the oral mucosa and the healing process examined
by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic
aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis
factor-α, interleukin-1β). Furthermore, we evaluated the radical-scavenging
activity of RJ and generation of keratinocyte growth factor from human
periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved
recovery from 5-FU-induced damage, reduced MPO activity and the production of
pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging
activity.
These data suggest that topical application of films that contain RJ
had a healing effect on the severe oral mucositis induced by 5-FU and that the
effect was caused by the anti-inflammatory or anti-oxidative activities of RJ.
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