Effect of Memo®, a natural formula combination, on
Mini-Mental State Examination scores in patients with mild cognitive impairment
Clin Interv Aging, 2013;8:975-81. doi: 10.2147/CIA.S44777.
Epub 2013 Jul 24.
BACKGROUND:
Mild cognitive impairment encompasses the clinical continuum
between physiologic age-related cognitive changes and dementia. A variety of
medications, including herbal preparations (in particular Ginkgo biloba and
Panax ginseng), have been advocated as treatments for cognitive impairment in
the elderly. In this study, we investigated the effect of an already marketed
dietary supplement (Memo®) combining 750 mg of lyophilized royal jelly with
standardized extracts of G. biloba 120 mg and P. ginseng 150 mg on Mini-Mental
State Examination (MMSE) scores in patients with mild cognitive impairment.
METHODS:
Sixty-six subjects presenting with forgetfulness and
satisfying the Diagnostic and Statistical Manual of Mental Disorders, 4th
Edition, Text Revision (DSM-IV-TR) clinical criteria for mild cognitive
impairment were randomly divided into an experimental group treated with one
Memo capsule before breakfast daily for 4 weeks and a control group who took
placebo. The mean change in MMSE score from baseline and reported adverse
effects were compared between the two groups.
RESULTS:
The mean change in MMSE score in the group treated with Memo
for 4 weeks was significantly greater than in the control group (+2.07 versus
+0.13, respectively) by the Student's t-test (t = 6.485, P < 0.0001). This
was also true after adjusting for age as a covariate and educational level as a
factor nested within the treatment groups in a general linear model (analysis
of covariance, F = 9.675 [corrected model], P < 0.0001).
CONCLUSION:
This combined triple formula may be beneficial in treating
the cognitive decline that occurs during the aging process as well as in the
early phases of pathologic cognitive impairment typical of insidious-onset
vascular dementia and in the early stages of Alzheimer's disease. Larger-sized
studies with longer treatment durations are needed to confirm this.
No comments:
Post a Comment