Royal jelly affects collagen crosslinking in bone of ovariectomized rats
Available online 11 February 2014
Royal jelly (RJ) is an essential food for queen bees, and it
reportedly has estrogen-like activity. The objective of this study was to
evaluate the effect of RJ intake on bone quality with a focus on the
posttranslational modifications of type I collagen. RJ was fed to
ovariectomized (OVX) rats for 12 weeks. RJ intake did not affect OVX-induced
reduction in bone volume at the femur epiphysis; however, the reduction of
collagen crosslinks (pyridinoline and deoxypyridinoline), which represent an aspect
of bone quality, were significantly mitigated. In cultured MC3T3-E1osteoblasts,
RJ treatment did not affect cell proliferation, cell differentiation, matrix
formation, or mineralization. However, RJ treatment did stimulate expression of
plods, which encode lysyl hydroxylase isoforms that control the collagen
crosslinking pathway, and it also affected collagen crosslinking.
These results
indicate that oral intake of RJ could improve bone quality by modulating the
posttranslational modification of type I collagen.
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