Effect of the Combination of Gelam Honey and Ginger on
Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic
Sprague-Dawley Rats
BioMed Research International, Volume 2014 (2014)
Diabetic complications occur as a result of increased
reactive oxygen species (ROS) due to long term hyperglycaemia. Honey and ginger
have been shown to exhibit antioxidant activity which can scavenge ROS. The
main aim of this study was to evaluate the antioxidant and antidiabetic effects
of gelam honey, ginger, and their combination.
Sprague-Dawley rats were divided into 2 major groups which
consisted of diabetic and nondiabetic rats. Diabetes was induced with
streptozotocin intramuscularly (55 mg/kg body weight). Each group was further
divided into 4 smaller groups according to the supplements administered:
distilled water, honey (2 g/kg body weight), ginger (60 mg/kg body weight), and
honey + ginger. Body weight and glucose levels were recorded weekly, while
blood from the orbital sinus was obtained after 3 weeks of supplementation for
the estimation of metabolic profile: glucose, triglyceride (TG), superoxide
dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced
glutathione (GSH): oxidized glutathione (GSSG), and malondialdehyde (MDA).
The combination of gelam honey and ginger did not show
hypoglycaemic potential; however, the combination treatment reduced
significantly () SOD and CAT activities as well as MDA level, while GSH level
and GSH/GSSG ratio were significantly elevated () in STZ-induced diabetic rats
compared to diabetic control rats.
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