Identification of the phenolic compounds contributing to
antibacterial activity in ethanol extracts of Brazilian red propolis
Published online: 25 Mar 2014
The purpose of this study is to identify the quantity and
antibacterial activity of the individual phenolic compounds in Brazilian red
propolis. Quantitative analysis of the 12 phenolic compounds in Brazilian red
propolis was carried out using reversed-phase high-performance liquid
chromatography. The main phenolic compounds in Brazilian red propolis were
found to be (3S)-vestitol (1), (3S)-neovestitol (2) and (6aS,11aS)-medicarpin
(4) with quantities of 72.9, 66.9 and 30.8 mg g of ethanol extracts− 1, respectively.
Moreover, the antibacterial activities of each compound against Staphylococcus
aureus, Bacillus subtilis and Pseudomonas aeruginosa were evaluated by
measuring the minimum inhibitory concentrations. In particular, compound 4
exhibited the most potent antibacterial activity among all the assayed
compounds against selected bacteria, indicating that 4 is the most active
compound in Brazilian red propolis extracts.
Thus, Brazilian red propolis may
be used as food additives and pharmaceuticals to protect against bacteria.
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