Neurological Effects of Honey: Current and Future Prospects
Evid Based Complement Alternat Med, 2014;2014:958721
Honey is the only insect-derived natural product with
therapeutic, traditional, spiritual, nutritional, cosmetic, and industrial
value. In addition to having excellent nutritional value, honey is a good
source of physiologically active natural compounds, such as polyphenols.
Unfortunately, there are very few current research projects investigating the
nootropic and neuropharmacological effects of honey, and these are still in
their early stages.
Raw honey possesses nootropic effects, such as
memory-enhancing effects, as well as neuropharmacological activities, such as
anxiolytic, antinociceptive, anticonvulsant, and antidepressant activities.
Research suggests that the polyphenol constituents of honey can quench
biological reactive oxygen species and counter oxidative stress while restoring
the cellular antioxidant defense system. Honey polyphenols are also directly
involved in apoptotic activities while attenuating microglia-induced
neuroinflammation. Honey polyphenols are useful in improving memory deficits
and can act at the molecular level.
Therefore, the ultimate biochemical impact of honey on
specific neurodegenerative diseases, apoptosis, necrosis, neuroinflammation,
synaptic plasticity, and behavior-modulating neural circuitry should be
evaluated with appropriate mechanistic approaches using biochemical and
molecular tools.
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