Anti-allergic Effect of Bee Venom in an Allergic Rhinitis
Mouse Model
Biol Pharm Bull, 2014;37(8):1295-300
Bee venom (BV) has been used as an anti-inflammatory and
immune modulating agent in Oriental medicine. This study used a mouse model to
investigate the anti-allergic effect of BV, which is used in the treatment of
various inflammatory diseases in traditional medicine. BV was obtained from the
National Institute of Agricultural Science and Technology of Korea. Female
BALB/C mice were sensitized by intraperitoneal injection of ovalbumin (OVA). BV
was administered nasally prior to the intranasal instillation of OVA. Allergic
behavior, serum OVA-specific immunoglobulin E (IgE), interleukin (IL)-4, IL-10,
and interferon-gamma (INF-γ) levels in nasal lavage fluid were measured.
Hematoxylin-eosin and periodic acid-Schiff staining were performed to evaluate
histological change. BV attenuated nasal symptoms and inhibited the production
of OVA-specific IgE and IL-4 in sensitized mice. The degree of inflammatory
cell infiltration and goblet cell hyperplasia was attenuated by BV. Thus, BV
effectively reduced allergic inflammation in a mouse model of allergic
rhinitis, suggesting its potential as a useful therapeutic agent to treat
allergic rhinitis.
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