Role of propolis (bee glue) in improving histopathological
changes of the kidney of rat treated with aluminum chloride
Environ Toxicol. 2014 Sep;29(9):1000-10
Humans are frequently exposed to aluminum from various food
additives, therapeutic treatments and the environment, and it can be
potentially toxic. This study is aimed to elucidate the protective effects of
propolis against aluminum chloride (AlCl3 )-induced histopathological and
immunohistochemical changes in kidney tissues of rats. Sixty Wistar Albino male
rats (average weight 250-300 g) were divided into three equal groups. The first
served as a negative control. The second received AlCl3 (34 mg/kg bw, 1/ 25 LD
50). The third were administered AlCl3 (34 mg/kg bw, 1/ 25 LD 50) plus propolis
(50 mg/kg bw). Doses were given once daily via a gavage for 8 weeks every day.
The results showed that shrunken glomeruli, intraglomerular congestion, loss of
apical microvilli, degeneration of mitochondria and widened rough endoplasmic
reticulum were also observed in the Proximal Convoluted Tubules of these
animals.
Treatment with propolis ameliorated the harmful effects of AlCl3 ;
this was also proved histopathologically by the noticeable improvement in the
renal tissues. There were also significant variations in the expressed of ki-67
and p53 proteins. It can be concluded that propolis may be promising as a
natural therapeutic agent in AlCl3 -induced renal toxicity and oxidative stress
in rat kidneys.
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