Preventive Effect of D-002, a Mixture of Long-Chain Alcohols From Beeswax, on the Liver Damage Induced with CCl4 in RatsJournal of Medicinal Food, 2007 Jun;10(2):379-83
D-002 is a mixture of higher aliphatic primary alcohols purified from beeswax with antioxidant effects.
Acute hepatotoxicity induced with CCl4 in rats has been related to increased hepatic lipid peroxidation and prevented with some antioxidants.
This study investigated whether D-002 could prevent the acute CCl4-induced hepatotoxicity in rats…
In conclusion, D-002 effectively prevented the histological liver disturbances and lowered MDA levels, a marker of cellular lipid peroxidation, in rats treated with CCl4.
Since increased liver lipid peroxidation has been postulated as a cause of CCl4-induced liver damage in rats, the preventive effects of D-002 could be due to its antioxidant action, but such a proposal still requires further research.
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