Saturday, July 19, 2008

Acute Consumption of Propolis Produced Mutagenic Effects

First In Vivo Evaluation of the Mutagenic Effect of Brazilian Green Propolis by Comet Assay and Micronucleus Test
Food and Chemical Toxicology, Volume 46, Issue 7, July 2008, Pages 2580-2584

Abstract: Propolis is a hive product containing chiefly beeswax and plant-derived substances such as resin and volatile compounds. Propolis has been used in various parts of the world as an antiseptic and wound healer since ancient times, and interest in the product has recently increased.

Considering the lack of data concerning the in vivo mutagenicity of green propolis, the capacity of this natural product to cause damage to the DNA was evaluated, using the alkaline single-cell gel electrophoresis (SCGE) and micronucleus test, in the peripheral blood cells of mice. The doses tested by gavage were 1000, 1500 and 2000 mg/kg.

Micronucleus and SCGE assays showed that green propolis caused an increase in the damage to DNA in the peripheral blood cells of mice. The polychromatic:normochromatic erythrocytes ratio was not statistically different from the negative control.

Considering the doses and the results obtained in this study, the acute consumption of green propolis produced some mutagenic effects on the blood cells of mice.

2 comments:

Julia said...

Considering the lack of data concerning the in vivo mutagenicity of green propolis, the capacity of this natural product to cause damage to the DNA was evaluated, using the alkaline single-cell gel electrophoresis (SCGE) and micronucleus test, in the peripheral blood cells of mice. The doses tested by gavage were 1000, 1500 and 2000 mg/kg.

tyanto said...

I hope you can explain the rest of this abstract.
Do you mean that green propolis can cause some mutagenic effects for us?