Propolis Extract Used to Prevent Cardiotoxicity by Anti-Cancer Drug

Cardioprotective Effects and Mechanism of Action of Polyphenols Extracted from Propolis Against Doxorubicin Toxicity
Pak J Pharm Sci, Jul 2008;21(3):201-9

Propolis is one of the major hive products of bees and is rich in flavonoids, which are known for antioxidant activities. It is well known that the chemical properties of phenolic acids or flavonoids, in terms of the availability of the phenolic hydrogens as hydrogen donating radical scavengers, predict their antioxidant properties.

In this study, the flavonoids scavenging activity of propolis has been exploited to obtain protection against the peroxidative damage in rat heart mitochondria which was induced by the administration of an acute dose of doxorubicin (20mg kg-1, i.p)…

The data demonstrate that antioxidants from natural sources may be useful in the protection of cardiotoxicity in patients who receive doxorubicin and as reported for its claimed beneficial effect on human health by biomedical literature.