Gelam Honey Has a Protective Effect against
Lipopolysaccharide (LPS)-Induced Organ Failure
Int. J. Mol. Sci, 2012, 13(5), 6370-6381
Gelam honey exerts anti-inflammatory and antioxidant
activities and is thought to have potent effects in reducing infections and
healing wounds.
The aim of this study was to investigate the effects of
intravenously-injected Gelam honey in protecting organs from lethal doses of
lipopolysaccharide (LPS).
Six groups of rabbits (N = 6) were used in this study. Two
groups acted as controls and received only saline and no LPS injections. For
the test groups, 1 mL honey (500 mg/kg in saline) was intravenously injected
into two groups (treated), while saline (1 mL) was injected into the other two
groups (untreated); after 1 h, all four test groups were intravenously-injected
with LPS (0.5 mg/kg). Eight hours after the LPS injection, blood and organs
were collected from three groups (one from each treatment stream) and blood
parameters were measured and biochemical tests, histopathology, and
myeloperoxidase assessment were performed. For survival rate tests, rabbits
from the remaining three groups were monitored over a 2-week period.
Treatment with honey showed protective effects on organs
through the improvement of organ blood parameters, reduced infiltration of
neutrophils, and decreased myeloperoxidase activity.
Honey-treated rabbits also showed reduced mortality after
LPS injection compared with untreated rabbits.
Honey may have a therapeutic effect in protecting organs
during inflammatory diseases.
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