Effect of Lyophilized Powder Made From Enzymolyzed Honeybee
Larvae on Tinnitus-Related Symptoms, Hearing Levels, and
Hypothalamus—Pituitary—Adrenal Axis-Related Hormones
Ear & Hearing, May/June 2012 - Volume 33 - Issue 3 - p
430–436
Objectives: Tinnitus interferes with sleep and concentration
which is associated with depression; however, no drug has been effective in
treating tinnitus. Our purpose is to evaluate our hypothesis that the treatment
with lyophilized powder of enzymolyzed honeybee larvae as a complementary
medicine may provide a therapeutic effect on tinnitus-related symptoms.
Design: Sixty tinnitus sufferers participated in a
randomized double-blind placebo-controlled trial using the lyophilized powder
of enzymolyzed honeybee larvae or a placebo. The Tinnitus Handicap Inventory, a
visual analog scale to rate the severity of tinnitus, hearing levels, and
hypothalamus–pituitary–adrenal axis-related hormones drawn early in the morning
were measured upon entry into the study and after 12 wk of follow-up.
Results: The lyophilized powder of enzymolyzed honeybee
larvae was not superior to placebo with regard to the total score on the
Tinnitus Handicap Inventory and the visual analog scale. However, subjects in
the honeybee larvae group showed significant improvements in some items about
depression associated with tinnitus, whereas subjects in the placebo group
showed no improvement in any items. The honeybee larvae group showed
significant improvements in the hearing levels at 2 and 4 kHz in the audiogram
of the better ear. The intervention of the lyophilized powder of enzymolyzed
honeybee larvae was associated with lower serum cortisol levels, serum
prolactin levels, and cortisol/dehydroepiandrosterone sulfate ratios. The
ratios in the placebo group significantly were increased.
Conclusions: Our results suggest that the lyophilized powder
of enzymolyzed honeybee larvae represents an effective complementary medicine
to alleviate depression associated with tinnitus by regulating the activity of
the hypothalamus–pituitary–adrenal axis.
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