The Anticancer Activity of Propolis
Folia Histochem Cytobiol, 2012 Apr 24;50(1):25-37]
Propolis and its compounds have been the subject of many
studies due to their antimicrobial and antiinflammatory activity; however, it
is now known that they also possess antitumor properties.
This review aims to summarize the results of studies on the mechanism of
activity of propolis and its active compounds such as CAPE and chrysin in the
apoptotic process, and their influence on the proliferation of cancer cells.
Our review shows that propolis and its presented compounds
induce apoptosis pathways in cancer cells. The antiproliferative effects of
propolis, CAPE or chrysin in cancer cells are the result of the suppression of
complexes of cyclins, as well as cell cycle arrest.
The results of in vitro and in vivo studies suggest that
propolis, CAPE and chrysin may inhibit tumor cell progression and may be useful
as potential chemotherapeutic or chemopreventive anticancer drugs.
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