Skin Sensitization Study of Bee Venom (Apis mellifera L.) in
Guinea Pigs and Rats
Cutan Ocul Toxicol, 2012 Jul 20
Background: Bee venom (Apis mellifera L., BV) possessing a rich
source of pharmacologically active substances has the potential to be used as a
cosmetic ingredient for antiaging, antiinflammatory and antibacterial
functions. The aim of this study was to assess the skin sensitization of BV on
experimental animals using the Buehler test.
Materials and methods: Guinea pigs were randomly allocated
into three groups of BV-sensitization, positive control-sensitization, and
ethyl alcohol-sensitization group for induction and challenge. On the other
hand, two groups of rats were administered with BV at doses of 0 and
1500 mg/kg. Clinical signs, mortality and body weight changes were continually
monitored during the study period.
Results: No treatment-related clinical signs or body weight
changes were observed in both animal models. The average skin reaction
evaluated by erythema and edema on the challenge sites, and sensitization rate
in the BV-sensitization group of guinea pigs were substantially low compared
with those in positive control group, representing a negligible sensitizing
potential of BV.
Conclusion: It was concluded that BV was well tolerated and
exhibited no dermal irritation potential in guinea pigs and rats. Our findings
may provide a developmental basis of BV for a cosmetic ingredient or external
application for topical uses.
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