Constituents of Honduran Propolis with Inhibitory Effects on
Saccharomyces cerevisiae Multidrug Resistance Protein Pdr5p
J Agric Food Chem, 2012 Sep 25. [Epub ahead of print]
Chemical investigation of a propolis sample collected in
Honduras has led to the isolation of the new (E,Z)-cinnamyl cinnamate (2)
together with 14 known compounds: six cinnamic ester derivatives, two
flavanones, a chalcone, two triterpenes and three aromatic acids. Structural
determination was accomplished by spectroscopic analysis, particularly 2D NMR
and ESI-MS/MS techniques. Futhermore, we checked the ability of propolis
extract and the most representative compounds of each class (1, 5, 8 and 10) to
inhibit the activity of Pdr5p, a protein responsible for a multidrug resistance
phenotype in yeast.
The present study appears to be the first report on Honduras
propolis. Isolated cinnamic ester derivatives indicated the possible relation
between Honduras propolis and the genus Liquidambar.
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