Effect of Royal Jelly Ingestion for Six Months on Healthy
Volunteers
Nutr J, 2012 Sep 21;11(1):77
BACKGROUND:
Royal jelly is a widely ingested supplement for health, but
its effects on humans are not well known. The objective was to evaluate the
effects of long-term royal jelly ingestion on humans.
METHODS:
We conducted a randomized placebo-controlled, double-blind
trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were
randomly divided into a royal jelly group (n = 31) and a control group (n =
30). Three hundred mg of royal jelly (RJ) or a placebo in 100 ml liquid/day
were ingested for 6 months. The primary outcomes were changes in anthropometric
measurements and biochemical indexes from baseline to 6 months after
intervention.
RESULTS:
Thirty subjects in the RJ group and 26 in the control group
were included in the analysis of endpoints. In an adjusted mean change of the
variables from the baseline, significant differences between the two groups
could be found in red blood cell counts (+0.16x106 /muL for the RJ group vs.
-0.01x106 /muL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%,
P = 0.0251), log (fasting plasma glucose) (+0.01 +/- 0.01 log mg/dL vs. +0.05
+/- 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P
= 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log mug/dL vs.
+0.20 log mug/dL, P = 0.0483), log testosterone (T) (+0.12 +/- 0.04 log ng/mL
vs. -0.02 +/- 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 +/- 0.05
vs. -0.23 +/- 0.59, P = 0.0015), and in one of the SF-36 subscale scores,
mental health (MH) (+4 vs. -7, P = 0.0276).
CONCLUSIONS:
Six-month ingestion of RJ in humans improved erythropoiesis,
glucose tolerance and mental health. Acceleration of conversion from DHEA-S to
T by RJ may have been observed among these favorable effects.
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