Biochem Biophys Res Commun, 2013 Feb 14
Propolis, a resinous mixture collected from plants by the
Apis mellifera bee, contains high level nutrient factors including vitamins,
polyphenols, and amino acids that would be expected to improve insulin
sensitivity. Insulin resistance would secondarily cause elevation of blood
pressure and increase the risk of cardiovascular diseases.
The purpose of this study is to investigate the effect of
propolis extracts on blood glucose levels and blood pressures in an early
developmental stage of insulin resistance in Otsuka Long-Evans Tokushima Fatty
(OLETF) rats. OLETF rats (10 weeks old) were divided into 3 different groups:
normal diet, 0.1% propolis diet, and 0.5% propolis diet. After 8 weeks, blood
glucose levels, blood pressures, plasma metabolic factors and hormones, and
interstitial fluid pH were measured. Casual blood glucose levels were decreased
associated with a reduction of plasma insulin levels in both proplois diet
groups compared with normal diet group. Propolis decreased systolic blood
pressure with no significant changes in plasma aldosterone levels. We also
found that interstitial fluid pH in ascites, liver, and skeletal muscle was
higher in rats fed propolis diet than rats fed normal diet.
These data suggests that dietary propolis improves insulin
sensitivity and blood pressures in the early stage of the process in
development of insulin resistance, which may be mediated by suppression of
metabolic acidosis.
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