J Pharmacol Sci, 2013 Jan 25
Oral mucositis induced by chemotherapy or radiotherapy has
an impact upon quality-of-life, is dose-limiting for chemotherapy, and causes
considerable morbidity. We evaluated the effect of royal jelly (RJ) on
5-fluorouracil (5-FU)-induced oral mucositis in hamsters.
Oral mucositis was induced in hamsters through a combination
of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in
chitosan-sodium alginate film (RJ film). Films were attached to the oral mucosa
and the healing process examined by measuring the area of mucositis,
myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection
of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β).
Furthermore, we evaluated the radical-scavenging activity of RJ and generation
of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ
films (10%, 30%) significantly improved recovery from 5-FU-induced damage,
reduced MPO activity and the production of pro-inflammatory cytokines.
Additionally, RJ showed radical-scavenging activity.
These data suggest that topical application of films that
contain RJ had a healing effect on the severe oral mucositis induced by 5-FU
and that the effect was caused by the anti-inflammatory or anti-oxidative
activities of RJ.
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