Burns, 2013 Jun;39(4):754-9
Bacterial contamination remains a constant threat in burn
wound care. Topical treatments to combat contaminations have good bactericidal
effects but can have detrimental effects for the healing process. Treatments
with for example silver can increase healing times. Honey based products can be
a good alternative as it is antibacterial and patient-friendly.
We evaluated the bactericidal and cytotoxic effects of a
honey based gel and silver sulphadiazine in a human burn wound model with
Pseudomonas aeruginosa.
After adding 10(5)colony forming units of P. aeruginosa,
topical treatments were applied on the burn wound models. After 2, 12, 24, 28
and 70h, bacteria were dislodged and counted by plating dilutions. Cytotoxic
effects were evaluated histologically in samples of burn wound models treated
topically for 3weeks, without bacteria.
l-Mesitran Soft significantly reduced the bacterial load
(5-log reduction) up to 24h but did not completely eliminate bacteria from the
burn wounds. After Flammazine(®) treatment, only a few colony forming units
were observed at all time points. In contrast, re-epithelialization was
significantly reduced after application of Flammazine(®) compared to l-Mesitran
Soft or control. This in vitro model of burn wound infection can be used to
evaluate topical treatments.
l-Mesitran Soft is a good alternative for treating burn
wounds but the slightly lower bactericidal activity in the burn wound model
warrants a higher frequency of application.
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