ISTANBUL, Turkey — A sterilized honey preparation was
effective in preventing infections at the site of peritoneal dialysis
catheters, according to a study presented here at the European Renal
Association-European Dialysis and Transplant Association (ERA-EDTA) 50th
Congress.
However, the honey preparation underperformed versus
mupirocin in patients with diabetes, said presenter Carolyn van Eps, PhD, staff
nephrologist at the Princess Alexandra Hospital, in Brisbane, Australia.
There is little evidence regarding the optimal strategy for
prevention of infection in peritoneal dialysis catheters. "Honey has
potential advantages," Dr. van Eps told Medscape Medical News. "A
very broad range of germs are covered by honey, including gram-positive and
gram-negative bacteria, and fungi, as well as multi-drug resistant organisms.
And it has not been shown in any study to induce antibiotic resistance, which
can be a problem with mupirocin. Honey also helps disrupt biofilms," which
can develop on the surface of catheters…
"Honey was not better and not worse compared to
mupirocin. Patients with diabetes seemed to do a bit worse when we used honey
compared to mupirocin, and there were more withdrawals from the trial in people
who used honey, and that was due to a combination of reasons because the
patients or physician wanted to withdraw, or they got a local reaction,"
said Dr. van Eps.
"For those reasons, honey is probably not the ideal
firstline recommendation, but it probably does have a role in patients who we
know have organisms that are resistant to mupirocin, or in patients who have
local reactions to mupirocin," she said…
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