Influence of caffeic acid phenethyl ester on bone healing in
a rat model
J Int Med Res, 2013 Sep 24
OBJECTIVE:
To examine the effects of caffeic acid phenethyl ester (CAPE;
a component of honey bee-hive propolis with antioxidant, anti-inflammatory,
antiviral and anticancer properties) on bone regeneration and fibrotic healing
in a rat model.
METHODS:
Male Sprague-Dawley rats (n = 63; mean age 7 weeks; weight
280-490 g) were randomly divided into three groups: A, cranial defect with no
bone healing treatment (n = 21); B, cranial defect treated with CAPE (n = 21);
C, cranial defect treated with CAPE and β-tricalcium phosphate/hydroxyl apatite
(n = 21). Rats were anaesthetized with ketamine (8 mg/100 g) by intraperitoneal
injection and a cranial critical size bone defect was created. Following
surgery, CAPE (10 µmol/kg) was administered by daily intraperitoneal injection.
Seven rats in each group were killed at days 7, 15 and 30 following surgery.
Bone regeneration, fibrotic healing and osteoblast activity were evaluated by
histopathology.
RESULTS:
Statistically significant differences in healing were found
between all groups. There were no statistically significant within-group
differences between day 7 and 15. At day 30, bone healing scores were
significantly higher in groups B and C compared with group A.
CONCLUSION:
CAPE significantly improved bone-defect healing in a rat
model, suggesting that CAPE has beneficial effects on bone healing.
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