Mucoadhesive Propolis Gel For Prevention Of Radiation-Induced
Oral Mucositis
Curr Clin Pharmacol, 2014 Feb 5
The objective of this phase II study was to determine the
effectiveness of a mucoadhesive propolis gel in the prevention of
radiation-induced oral mucositis.
Twenty-four patients who were selected to undergo radiation
therapy for oral cancer were included in this open-label trial. They were
advised to use a mucoadhesive gel containing propolis 5,0% w/v three times a
day starting one day before the course of radiation therapy and concluding
after 2 weeks of radiation therapy. A weekly follow-up for evaluation of food
intake, pain and grading of mucositis was performed.
In order to confirm the absence of Candida-related mucositis
in patients who developed mucositis, it was performed exfoliative cytology of
buccal mucosa, palate and tongue and the material for Candifast® Candida
species identification. At the end of the study was made the compliance of
patients, quality, appreciation and acceptance of product evaluation.
Twenty patients did not develop mucositis, two patients
developed grade 1 mucositis and two patients developed grade 2 mucositis. None
of the patients discontinued food intake and no pain was observed during the
study. Candidosis was not detected in any patient.
Mucoadhesive propolis gel could be considered as a potential
topical medication for preventing radiation-induced oral mucositis. However,
comparative phase III study with larger number of patients should be done for
confirmation of the efficacy of the product.
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