Stimulatory Effect of Brazilian Propolis on Hair Growth
through Proliferation of Keratinocytes in Mice
J Agric Food Chem. 2014 Nov 26. [Epub ahead of print]
Propolis is a natural honeybee hive product with the
potential for use in the treatment of dermatological conditions, such as
cutaneous abrasions, burns, and acne. In this study, we investigated whether
propolis stimulates hair growth in mice. Ethanol-extracted propolis, which
contains various physiologically active substances such as caffeic acid and
kaempferol, stimulated anagen induction in shaved back skin. Anagen induction
occurred without any detectable abnormalities in the shape of the hair
follicles (HFs), hair stem cells in the bulge, proliferating hair matrix
keratinocytes in the hair bulb, or localization of versican in the dermal
papilla.
Propolis treatment also stimulated migration of hair matrix
keratinocytes into the hair shaft in HFs during late anagen in the depilated
back skin. Organotypic culture of skin containing anagen stage HFs revealed
significant stimulation of hair matrix keratinocyte proliferation by propolis.
Furthermore, propolis facilitated the proliferation of epidermal keratinocytes.
These results indicate that propolis stimulates hair growth by inducing hair
keratinocyte proliferation.
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