Effects of an ethanol extract of Brazilian green propolis on
human cytochrome P450 enzyme activities in vitro
Publication Date (Web): October 31, 2014
Supplement-drug interaction on CYP enzyme activity are
occasionally found to cause clinically adverse events, and no report on
interactions of propolis is available either in vitro or clinical. In this
study, we tried to estimate the risk of an interaction between an ethanol
extract of Brazilian green propolis (EEP-B55) and drugs in vitro and in vivo.
The activities of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 were attenuated
by EEP-B55 in a concentration-dependent manner, and artepillin C, kaenpferide,
dihydrokaempferide, isosakuranetin, and kaempferol were estimated to have
potential for CYP inhibition. The IC50 values of artepillin C for each CYP were
approximately 33-fold higher than its Cmax in the blood of rats after dosing
with 5-fold the recommended daily intake of EEP-B55. These findings suggest
that liver CYP enzyme activities are not markedly affected by artepillin C at
the recommended daily intake of EEP-B55.
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