Thursday, June 10, 2021

Antimicrobial Activities of Green and Red Brazilian Propolis

Green and red Brazilian propolis: antimicrobial potential and anti-virulence against ATCC and clinically isolated multidrug-resistant bacteria

Chem Biodivers. 2021 Jun 4

Brazilian green and red propolis stand out as commercial products for different medical applications. In this paper, we report the antimicrobial activities of the hydroalcoholic extracts of green (EGP) and red (ERP) propolis, as well as guttiferone E plus xanthochymol (8) and oblongifolin B (9) from red propolis, against multidrug-resistant bacteria (MDRB). 

We undertook the minimal inhibitory (MIC) and bactericidal (MBC) concentrations, inhibition of biofilm formation (MICB 50 ), catalase, coagulase, DNase, lipase, and hemolysin assays, along with molecular docking simulations. ERP was more effective by displaying MIC and MBC values < 100 μg.mL -1 . 

Compounds 8 and 9 displayed the lowest MIC values (0.98 to 31.25 µg.mL -1 ) against all tested Gram-positive MDRB. They also inhibited the biofilm formation of S. aureus (ATCC 43300 and clinical isolate) and S. epidermidis (ATCC 14990 and clinical isolate), with MICB 50 values between 1.56 and 6.25 µg.mL -1 . The molecular docking results indicated that 8 and 9 might interact with the catalase's amino acids. Compounds 8 and 9 have great antimicrobial potential.

Monday, June 07, 2021

Mountain Tallow Tree Honey Protects Against Alcohol-Induced Liver Disease

Monofloral Triadica Cochinchinensis Honey Polyphenols Improve Alcohol-Induced Liver Disease by Regulating the Gut Microbiota of Mice

Front Immunol. 2021 May 21;12:673903

Honey produced from medicinal plants holds great promise for human health. Increasing evidence suggests that the gut microbiota plays an important role in liver pathology after alcohol intake. The aim of this study was to identify the polyphenol composition of triadica cochinchinensis honey (TCH), and to study the potential effect of honey polyphenols on the regulation of gut microbes in mice with alcohol-induced liver injury and the improvement of alcohol-induced liver disease. For these purposes, a total of 190 compounds were identified and 27 of them were quantified by ultraperformance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and we successfully established a mouse model of alcohol-induced liver injury. The results show that TCH polyphenols can significantly restore the levels of ALT and AST, and TCH intervention can significantly improve the pathological changes of liver tissue in alcohol-exposed mice. Additionally, a significant decrease was observed in Firmicutes/Bacteroidetes after TCH treatment. Moreover, KEGG pathways of ATP-binding cassette (ABC) transporters, two-component system and biosynthesis of amino acids enriched the most differentially expressed genes after TCH intervention for 8 weeks. Our results may have important implications for the use of TCH as a functional food component with potential therapeutic utility against alcohol-induced liver disease.

Saturday, June 05, 2021

Bee Pollen May Help Treat/Prevent Diabetes and Obesity, Delay Aging, Enhance Immunity, Boost Mental (Brain) Activity and Fertility, Protect Heart

Bee Pollen: Current Status and Therapeutic Potential

Nutrients. 2021 May 31;13(6):1876

Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.


Global interest and the increase of consumer awareness, especially regarding the nutritional and medicinal value of what they eat or drink, awaken the concept of returning to natural products, especially bee products. Bee pollen has had attracted a big deal of focus from the food supplement and food processing industries due to its high health value. The involvement of bee pollen in various formulations i.e., pills, tablets, capsules, and powders, helped to cover many customers’ needs. Bee pollen has served to prevent and treat many chronic diseases, especially metabolic disorders. It has a preventive role in various ailments such as diabetes, obesity, hyper-dyslipidemia, and heart complications. Bee pollen was recommended as a daily supplement to maintain a healthy weight. Additionally, bee pollen as a functional food can be used daily to protect against heart muscle diseases and the harmful impacts of food toxins. Long-term bee pollen consumption can improve health, foster blood circulation, delay aging, enhance immunity and increase physical and mental activities. More studies on metabolic pathways and biomedical interactions are required to establish bee pollen’s bioactivity in controlling body functions and preventing diseases. Boosting clinical practice and encouraging the search for bee pollen products play a significant role in fostering future innovations and possible applications.

Tuesday, June 01, 2021

Royal Jelly Can Play Anti-Inflammatory Role, Protect Kidney and Liver

The effect of royal jelly and silver nanoparticles on liver and kidney inflammation

Avicenna J Phytomed. May-Jun 2021;11(3):218-223

Objective: Royal jelly (RJ) is a honey bee product for which, anti-inflammatory properties were shown in vitro. Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver.

Materials and methods: In this project, 40 male rats were grouped as follows: 10 rats as controls, 10 rats treated with RJ; 10 rats treated with both NS and RJ and 10 rats treated with NS. Liver and kidney interleukin (IL)-1β, -2, -6, and -33 levels were determined using commercial ELISA kits.

Results: RJ reduced kidney IL-6 levels in comparison to control and NS--RJ groups. RJ and NS reduced kidney and liver IL-1β levels. Kidney IL-33 levels were decreased in the RJ and nano-silver groups in comparison to the NS--RJ group.

Conclusion: Based on this study, it may be concluded that RJ together with NS can play anti-inflammatory roles and may affect the function of immune cells.

Thursday, May 27, 2021

Fighting Eye Diseases with Brazilian Green Propolis

Biomedicine & Pharmacotherapy
Volume 140, August 2021, 111740

In 2020, an estimated 596 million people worldwide had distance vision impairment and a further 510 million had uncorrected near vision impairment, which can profoundly affect individuals, families, and society. Currently, the ultimate goal in ophthalmology research is to establish news actions other than medical that may be effective for the treatment of eye diseases. To a similar extent, as nature has provided an unlimited source of biologically-active compounds, scientists have sought resources in fauna and flora to treat certain major eye diseases. Thus, we enjoyed reading the excellent review article developed by Zhao and colleagues who discussed the latest developments in therapeutic quercetin for the treatment of various ophthalmic diseases. Due to various biological activities, such as antioxidant, anti-inflammatory, and anti-fibrosis activities, the authors appropriately discuss the clinical application of quercetin in keratoconus, Graves’ orbitopathy, ocular surface, cataracts, glaucoma, retinoblastoma, and other retinal diseases.

Considering the important clinical data, we also would like to express some thoughts that may open the debate about the possible viability of propolis in the ophthalmological field. In fact, as pure natural molecules isolated from plants have shown scientifically-proven benefits for ocular tissues, the protective effects of propolis in certain major eye diseases could play an important role in this scenario...

Wednesday, May 26, 2021

Bee Venom May Help Treat Aggressive, Hard-to-Treat Breast Cancer

Beekeepers are in the early stages of trials to assess the benefits of bee venom.

Key points:
  • A Northern NSW apiarist is exploring how beekeepers can diversify
  • Research has found honeybee venom is effective in killing breast cancer cells
  • It could provide more options for apiarists than just honey production
...She said her business HoneyBee Hives, which operates from Coutts Crossing, would be using Queensland-invented technology to see if bee venom could be used for both cosmetic and therapeutic purposes.

The technology, developed by company Whale Labs, is a bee venom collection device that doesn't harm the bees.

"Rather than just doing the same old, same old, let's look at ways we can diversify," Ms McQueen-Richardson said.

A study published in the Nature Precision Oncology journal last year found venom from honeybees could rapidly kill aggressive and hard-to-treat breast cancer cells.

The study also found when the venom's main component was combined with existing chemotherapy drugs, it was extremely efficient at reducing tumour growth in mice.

Wednesday, May 19, 2021

WATCH: Can Bee Venom Therapy Help Treat Lyme Disease?

Bee venom therapy?

SOUTH BEND, Ind. (WNDU) - This woman’s only relief from Lyme disease is bees!

Stinging away the pain of Lyme disease, in today’s Medical Moment.

300,000 people are diagnosed with Lyme disease each year.

If diagnosed early, antibiotics will wipe out the bacteria left behind in the blood before it spreads.

But now, as Martie Salt reports, some patients are turning to bees.

The scientists caution that more research is needed to find a safe and effective way to administer the bee venom.

And of course, health experts say people who are allergic to bees should not try this.

Tuesday, May 18, 2021

The Health Benefits of Bee Pollen (bee bread, anti-inflammatory, antimicrobial, and antiviral properties, allergies, allergy)

Bee pollen: What to know

  • About bee pollen
  • Nutritional details
  • Apitherapy
  • Potential health benefits
  • Precautions
  • Pollen and bees
  • Medical advice

Bee pollen provides nutritional food for bees. It is a natural mixture of bee secretions, honey, enzymes, wax, and flower pollen. Bee pollen may have some benefits for humans, but collecting it may adversely affect the health of the bees and even destroy the colony.

Many people regard bee pollen as a superfood because of its many nutrients; others see it as a natural therapeutic product that has anti-inflammatory, antimicrobial, and antiviral properties. Consuming bee pollen may not suit people with allergies to flower pollen or bee stings...

Friday, May 14, 2021

Bee Bread May Help Prevent Complications of Type 2 Diabetes

Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats

Molecules. 2021 Apr 29;26(9):2616

This study examined for the first time whether bee bread (BB, consisting of monofloral rape bee pollen) could alleviate lipid derangements and reduced bone quality in Zucker diabetic fatty (ZDF) rats, which are considered an appropriate animal model for type 2 diabetes mellitus (T2DM) investigation. Adult ZDF rats were segregated into four groups: lean non-diabetic rats (L group), obese diabetic rats untreated (C group), and those treated with the BB at two doses (500 and 700 mg/kg body weight, respectively, B1 and B2 groups) for 10 weeks. Significantly reduced levels of total cholesterol and triglyceride were recorded in the B2 group versus the C group. In both BB-treated groups, significantly increased relative volume of trabecular bone and trabecular thickness, enhanced density of secondary osteons, accelerated periosteal bone apposition, and improved blood flow were observed. A positive effect of higher dose of BB on femoral weight and cortical bone thickness was also demonstrated. Our results suggest a promising potential of BB to ameliorate T2DM-related complications associated with lipid and bone damages.

Friday, May 07, 2021

Using Bee Venom as a Treatment for Lyme Disease


...Adriana and her mother talked with 75 different doctors, tried antibiotics, immunotherapy, hyperbaric oxygen and herbal treatments. Nothing worked until bee venom therapy, or BVT. Ellie Lobel, a nuclear physicist, literally stumbled across the treatment by accident.

“I was attacked by killer bees,” Ellie Lobel shared.

But days after surviving the surprise bee attack her symptoms started disappearing. Ellie spent the next several years researching BVT and found it kills the bacteria that causes Lyme’s most debilitating symptoms—but according to Ellie, it only works if taken directly from the bee.

“The devil’s in the dosing right, is what they say. So not enough, won’t heal you, but too much can kill you,” Lobel revealed...

Thursday, May 06, 2021

International Virtual Conference: Apitherapy for Children - Bees, Children and Health, 22nd to 24th of October 2021

The main topics of the conference: 

    • Medicinal bee plants useful for bees and children

    • Medicinal beekeeping, rules, and principles

    • Bio-pharmacology and quality of beehive products

    • Prevention and treatment of children diseases, including allergies with beehive products

    • Api-Tourism and Api-Education for Children

Sunday, May 02, 2021

Honey Most Commonly Used Dietary Supplement Used in Saudi Arabia During COVID-19 Pandemic

COVID-19 Pandemic in Saudi Arabia:
A Cross-Sectional Online Survey

Objectives: The utilization rate of herbal and dietary supplements among the Saudi population is reported to be high. However, the utilization rate and types of herbal and dietary supplements during the COVID-19 pandemic are largely unknown.

Methods: This was an online questionnaire-based cross-sectional study that used convenience sampling and social media platforms (Telegram®, Twitter®, and WhatsApp®) to disseminate a 12-item questionnaire across the Saudi general public aged 18 years and above. The questionnaire inquired about the sociodemographic characteristics (e.g., age, gender, education, geographical location), presence of chronic health conditions and the use of prescription medications, awareness of the viral nature of COVID-19 infection and its common symptoms, and the commonly utilized herbal and/or dietary supplements.

Results: Sixty-four percent of the 1473 participants reported using herbal and/or dietary supplements for the purpose of boosting their immune system to prevent COVID-19 infection. In addition, 88.2% of the respondents were misinformed about the manifestation of COVID-19 symptoms. Most of the participants were Saudi (91.9%), aged 49 years and younger (83%), female (52%), and healthy (81%). Honey (46%), lemon (45%), ginger (36%), vitamin C (32%), black seed (26%), garlic (26%), and turmeric (19%) were the most commonly used herbal and/or dietary supplements by the participants. Saudi nationals (OR = 1.67, 95% CI: 1.08 to 2.6, p = 0.02), older adults (OR = 1.30, 95% CI:1.10 to 1.55, p = 0.002), and those taking prescription medications had higher odds of using dietary and/or herbal supplements (OR = 3.31, 95% CI: 2.61 to 4.18, p < 0.0001).

Conclusion: The utilization rate of herbal and dietary supplements among the Saudi public during the COVID-19 pandemic is high. Future studies should examine the impact of different public awareness campaigns aimed at improving the public knowledge of the risk and benefits associated with the use of different commonly utilized herbal and dietary products identified in this study.

Tuesday, April 27, 2021

Royal Jelly Protects Brain Against Chronic Stress, Improves Behavioral and Cognitive Impairments

Combined effects of royal jelly and environmental enrichment against stress-induced cognitive and behavioral alterations in male rats: behavioral and molecular studies

Nutr Neurosci. 2021 Apr 5;1-12

Background: Exposure to chronic stress has detrimental effects on cognitive and emotional processing. Also, the neuroprotective influences of environmental enrichment (EE) and royal jelly (RJ) have been indicated in previous studies.

Aims: To our knowledge, to date, there are no studies about the synergistic effects of EE and RJ on cognitive changes induced by stress. Therefore, this study aimed to investigate the protective effects of RJ, and EE on anxiety-like behaviors, cognitive functions, and expression of hippocampal and also prefrontal cortex (PFC) brain-derived neurotrophic factor (BDNF) levels in stressed rats.

Methods: By using restraint and cold temperature, rats were exposed to stressful situations and then subjected to treatment with RJ or/ and EE for 14 days. Stress induction was done 14 days before treatments by placing the rats in the restrainer under 4°C. Following the interventions, anxiety-like behaviors, novel object recognition memory (NORM), inhibitive avoidance performance, hippocampal, and PFC BDNF expression were examined. The plasma corticosterone level of all groups was also evaluated.

Results: Results showed increased plasma corticosterone levels, stress-induced deficits in the NORM and IA tests, and increased anxiety-like behaviors. EE and RJ improved these deficits with a decline in serum corticosterone and also increased BDNF levels in the hippocampus and PFC in stressed ones.

Conclusion: The EE and the RJ prevented the detrimental effects of stress on anxiety-like behaviors and memory processes. These treatments can protect susceptible brain areas against chronic stress via improvement in behavioral and cognitive impairments through mediating BDNF expression.

Monday, April 26, 2021

Wasp and Bee Venom May Help Treat Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease)

Anti-Inflammatory Effect of Wasp Venom in BV-2 Microglial Cells in Comparison with Bee Venom

Insects. 2021 Mar 29;12(4):297

The aim of this study was to compare the anti-inflammatory effect of wasp venom (WV) from the yellow-legged hornet (Vespa velutina) with that of bee venom (BV) on BV-2 murine microglial cells. 

WV was collected from the venom sac, freeze-dried, and used for in vitro examinations. WV and BV were non-toxic to BV-2 cells at concentrations of 160 and 12 µg/mL or lower, respectively. 

Treatment with WV reduced the secretion of nitric oxide and proinflammatory cytokines, including interleukin-6 and tumor necrosis factor alpha, from BV-2 cells activated by lipopolysaccharide (LPS). 

Western blot analysis revealed that WV and BV decreased the expression levels of inflammation markers, including inducible nitric oxide synthase and cyclooxygenase-2. In addition, WV decreased the nuclear translocation of nuclear factor κB (NF-κB), which is a key transcription factor in the regulation of cellular inflammatory response. 

Cumulatively, the results demonstrated that WV inhibited LPS-induced neuroinflammation in microglial cells by suppressing the NF-κB-mediated signaling pathway, which warrants further studies to confirm its therapeutic potential for neurodegenerative diseases.

Saturday, April 24, 2021

Bee Venom Therapy Used to Treat Lyme Disease

Stinging away Lyme disease with bee venom therapy?

Three-hundred-thousand people are diagnosed with Lyme disease each year. Usually caused by a tick bite, it can impact people physically, mentally, and neurologically.

If diagnosed early, antibiotics will wipe out the bacteria left behind in the blood before it spreads through the heart, joints and nervous system.

Now, some patients are turning to bees to take the sting out of this painful and debilitating disease.

One sting -- after another -- after another. These days, Adriana Furey stings herself with ten live honeybees three times a week to get relief from the symptoms of chronic Lyme disease...