Thursday, November 26, 2020

Bee Venom May Help Treat Arthritis (Osteoarthritis, Rheumatoid Arthritis, Psoriatic Arthritis, Pain, Stiffness, Swelling, Inflammation)


Investigation of anti-inflammatory effects of bee venom in experimentally induced adjuvant arthritis


Reumatologia. 2020;58(5):265-271

Abstract

Objectives: Rheumatoid arthritis is a multisystemic inflammatory disease characterized by destruction of the joints. An effective treatment method of the disease has not been developed yet. The aim of the present study is to evaluate the effects of bee (Apis mellifera anatoliaca) venom (BV) on serum inflammatory parameters, serum antioxidant load and clinical parameters of experimentally induced adjuvant arthritis in rats.

Material and methods: A total of 35 Wistar albino male rats were used. The animals were divided into 5 groups. First group animals served as negative controls. The second, third, fourth and fifth groups were used for experimental arthritis induction. Following clinical development of arthritis, the first group was subcutaneously administered 0.2 ml of physiological saline, and the second, third and fourth groups were treated subcutaneously with 2 µg/kg, 4 µg/kg and 20 µg/kg once a week three times. Physiological saline injected fifth group animals were used as a sham-treatment group. Clinical observations and evaluation of arthritis were made at the 15th day, and at the end of the experiment. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, paraoxonase, serum aryl esterase, high-sensitivity C reactive protein, interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) were determined in cardiac blood samples taken at the end of the 29th day.

Results: From the data, total oxidant level (TOL) and oxidative stress index (OSI) were calculated. Significant improvements were observed in the clinical signs of arthritis and inflammatory markers such as in IL-1β, TNF-α, IL-6 and TOL and OSI in the 20.0 µg/kg BV-administered group. Bee venom administration did not cause any significant increase in ALT and AST values or signs of liver toxicity.

Conclusions: Bee venom treatment was effective in alleviation of symptoms of the experimental rat adjuvant arthritis by means of clinical observation and serum inflammatory markers.

Tuesday, November 24, 2020

Bee Bread, Bee Pollen Show Antimicrobial Activity

Bee-collected pollen (BCP) is a well-known functional food. Honey bees process the collected pollen and store it in the hive, inside the comb cells. The processed pollen is called bee- bread or ambrosia and it is the main source of proteins, lipids, vitamins, macro-and micro-elements in honey bee nutrition. During storage, beebread undergoes solid state fermentation which preserves it and increases the bioavailability of nutrients. Research on beebread has been rather limited until now. In recent years, there is an increasing interest regarding the antimicrobial properties of BCP and beebread, due to emerging antimicrobial resistance by pathogens. Both BCP and beebread exhibit antimicrobial properties against diverse pathogens, like bacteria and fungi. As is the case with other bee products, lack of antimicrobial resistance might be attributed to the synergy of more than one antimicrobial compounds within BCP and beebread. Furthermore, BCP and bee bread exert targeted activity against pathogens and affect the host microbiome in a prebiotic manner. This review aims to present up to date research findings regarding these aspects as well as to discuss current challenges and future perspectives in the field.

...BCP or BB demonstrate selective antimicrobial activity that is usually higher against Gram-positive compared to Gram-negative bacteria. Strain specificity should be further investigated to identify BCP/BB compounds responsible for that. In that respect more studies should be conducted towards exploring synergy of BCP and BB extracts (or compounds detected within) and antibiotics. This synergy could prevent or delay microbial resistance which is a major public health issue.



Thursday, November 12, 2020

Invitation to the Online Romanian Apitherapy Congress, Nov. 20-22, 2020


The Romanian Apitherapy Society is offering next week-end (November 20-22), through ZOOM online platform, free access to our international speakers and regular participants.

For more details please check our website: http://www.apiterapie.ro/en/the-xiii-th-romanian-apitherapy-congress/

Please share this info with all your best friends and colleagues from your own national Apitherapy Associations/groups.

We have a limited number of seats in the conference room, so hurry-up with your registration.

Best regards from Romania,

Yours all,

Dr. Stefan Stangaciu

E-mail: drstangaciu@gmail.com + drstangaciu@apitherapy.com

Sunday, November 08, 2020

How to Make Homemade Antibiotic with Turmeric and Honey


Ingredients:
  • 1 tablespoon of turmeric
  • 100 grams of honey (Buckwheat Honey is Great) 
Instructions:

In a glass jar, mix the ingredient, and stir well.

Take a tablespoon of the remedy on every hour to treat the flu. Do not swallow it immediately, but leave it to melt in the mouth. On the next day, take the same amount but on every 2 hours, and repeat on the third day, taking it only three times daily.

You can also add it to your tea or milk.

Friday, October 23, 2020

Propolis Spray Helps Treat Viral and Bacterial Upper Respiratory Tract Infections (COVID, COVID-19, Coronavirus, Pandemic)


A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): A monocentric, randomized, double-blind, placebo-controlled clinical trial


Phytomedicine. 2020 Oct 8;80:153368. 

Abstract

Background: The most common symptoms of mild upper respiratory tract infections (URTIs) are sore throat, muffled dysphonia, and swelling and redness of the throat, which result from the inflammation process following acute bacterial or viral infection.

Hypothesis/purpose: As propolis is a natural resinous substance traditionally used to maintain oral cavity and upper respiratory tract health due to its antimicrobial and anti-inflammatory properties, the aim of this study is to evaluate the efficacy of an oral spray based on poplar-type propolis extract with a known and standardized polyphenol content, on the remission of the symptoms associated with mild uncomplicated URTIs.

Study design: A monocentric, randomized, double-blind, placebo-controlled clinical trial was performed.

Methods: This study was conducted in 122 healthy adults who had perceived mild upper respiratory tract infections. Participants, randomly assigned to receive either propolis oral spray (N = 58) or placebo (N = 64), underwent four visits (baseline = t0, after 3 days = t1 and after 5 days = t2 and after a follow-up of 15 days = t3) in an outpatient setting. Propolis oral spray total polyphenol content was 15 mg/ml. The dosage was 2-4 sprays, corresponding to 12-24 mg of polyphenols, three times for five days. The duration of the study was 8 weeks.

Results: After 3 days of treatment, 83% of subjects treated with propolis oral spray had remission of symptoms, while 72% of subjects in the placebo group had at least one remaining symptom. After five days, all subjects had recovered from all symptoms. This means that resolution from mild uncomplicated URTIs took place two days earlier, instead of taking place in five days as recorded in the control group. There was no relationship between the ingestion of propolis oral spray or placebo and adverse reactions.

Conclusion: Propolis oral spray can be used to improve both bacterial and viral uncomplicated URTI symptoms in a smaller number of days without the use of pharmacological treatment, leading to a prompt symptom resolution.

Thursday, October 22, 2020

Italian Bee Pollens Show Antioxidant, Nutraceutical Properties (B2, B3, B6, B9, Amino Acids, Polyphenols, Flavonoids, Omega-3, Omega-6)


Antioxidant, Nutraceutical Properties, and Fluorescence Spectral Profiles of Bee Pollen Samples from Different Botanical Origins


Antioxidants (Basel), 2020 Oct 15;9(10):E1001

Bee pollen is made by honey bees (Apis Mellifera) from the pollen of plants and flowers and represents an apiary product enriched in essential amino acids, polyphenols, omega-3, and omega-6 fatty acids. 

This study investigated the botanical origin, micronutrient profile, and antioxidant activity of bee pollen samples (n = 10) harvested in Lucca and Massa Carrara (Tuscany, Italy) between 2016 and 2017. The palynological analysis showed that bee pollen samples were composed of nine botanical families. Front-face fluorescence spectroscopy was performed on bee pollen samples in bulk, without any treatment, and in ethanol extracts to determine the characteristic fluorescent profile and, to identify the main chemical compounds with biological activity. 

The main chemical compounds detected were polyphenols (mainly flavonoids and phenolic acids), hydro-soluble vitamins (B2, B3, B6, and B9), amino acids, and pigments. Furthermore, the antioxidant activity was investigated, and one of the two Viburnum pollens resulted in the highest polyphenols and flavonoids content (20.15 ± 0.15 mg GAE/g fw and 23.46 ± 0.08 mg CE/g fw, respectively). However, Prunus and Eucalyptus families showed the highest in vitro (190.27 ± 8.30 µmol Fe2+/g) and ex vivo (54.61 ± 8.51 CAA unit) antioxidant capacity, respectively. 

These results suggested that Tuscan bee pollen, depending on the botanical family, is rich in essential nutrients and potential nutraceutical product.

Wednesday, October 14, 2020

Bee Pollen and Propolis May Help Treat Breast Cancer


Water-soluble propolis and bee pollen of Trigona spp. from South Sulawesi Indonesia induce apoptosis in the human breast cancer MCF-7 cell line

Oncol Lett. 2020 Nov;20(5):274

Bee products are best known as one of the beneficial natural products providing multiple pharmacological effects, such as antimicrobial, antiviral, anti-inflammatory and anticancer effects. The present study aimed to identify potent products derived from the stingless bee Trigona spp. from Luwu Utara (South Sulawesi, Indonesia), focussing on the water-soluble extract of propolis and bee pollen, against the proliferation of the human breast cancer MCF-7 cell line.

The results from DPPH (2,2-diphenyl-1-picrylhydrazyl) method of antioxidant assay revealed that water-soluble propolis and bee pollen had high antioxidant activity, with half-maximal effective concentrations against DPPH radicals of 1.3 and 0.4 mg/ml, respectively...

The present results suggested that water-soluble propolis and bee pollen may have the potential to be elaborated further as a breast anticancer therapy.

Saturday, October 10, 2020

Preparing Bee Bread Caviar from Buckwheat Honey


Preparation of Beebread Caviar from Buckwheat Honey through Immobilization with Sodium Alginate


Molecules. 2020 Sep 29;25(19):E4483.

Honeys have a pleasant taste and a wide range of use. They are characterized by a relatively high consumption compared to bee pollen or beebread. Honeys are the most popular bee products. Considering health reasons, beebread exhibits the strongest properties as it has the highest nutritional value as well as strong detoxifying, antioxidant, and antiradical properties. Despite having such valuable properties, consumption of beebread is negligible; sometimes, it is limited only to supplementation in case of diseases. This paper proposes a new food product, that is, beebread caviar made from buckwheat honey. The expiry date and sensory and physicochemical quality of beebread caviar have been determined in this study. Beebread caviar, obtained by immobilization on alginate carrier, contained 0.34 mg GAE/mL extract. It remained stable until five days after preparation. Its total acidity was 33.7 mval/kg. Its extract content was 22.53%. Caviar had a high overall sensory score of 4.8 points on a 5-point scale. Beebread caviar can be successfully classified as probiotic food because beebread contains a large amount of lactic acid. In the form of caviar, a new, attractive, and convenient form of beebread consumption could become one of the products of comfortable and functional food.

Saturday, September 19, 2020

Apitherapy Could Mitigate Some Risks Associated with COVID‐19/Coronavirus (SARS‐CoV‐2, Treatment, Prophylactic)


Bee products as a source of promising therapeutic and chemoprophylaxis strategies against COVID‐19 (SARS‐CoV‐2)


Phytotherapy Research

The emergence of novel coronavirus (SARS‐CoV‐2) in 2019 in China marked the third outbreak of a highly pathogenic coronavirus infecting humans. The novel coronavirus disease (COVID‐19) spread worldwide, becoming an emergency of major international concern. However, even after a decade of coronavirus research, there are still no licensed vaccines or therapeutic agents to treat the coronavirus infection.

In this context, apitherapy presents as a promising source of pharmacological and nutraceutical agents for the treatment and/or prophylaxis of COVID‐19. For instance, several honeybee products, such as honey, pollen, propolis, royal jelly, beeswax, and bee venom, have shown potent antiviral activity against pathogens that cause severe respiratory syndromes, including those caused by human coronaviruses. In addition, the benefits of these natural products to the immune system are remarkable, and many of them are involved in the induction of antibody production, maturation of immune cells, and stimulation of the innate and adaptive immune responses.

Thus, in the absence of specific antivirals against SARS‐CoV‐2, apitherapy could offer one hope toward mitigating some of the risks associated with COVID‐19...

Bee products are known for their several medicinal and pharmaceutical properties, which have been explored since the beginning of society. Of these, the antiviral effect and the ability to stimulate the immune system using bee products stand out as potentially promising alternative in the therapy of severe viral respiratory infections, such as COVID‐19.

Moreover, except for bee venom, apicomplexes are generally well tolerated and readily available, which can contribute to wide access in times of pandemic. The immunomodulatory, antiviral, anti‐inflammatory, antioxidant, and pro‐resolving effects of different bee products and their chemical components can be useful in prophylaxis, specific treatment, and even symptomatic treatment of COVID‐19. However, the number of current evidence is overwhelming, and large randomized and controlled clinical trials should be conducted to assess the real benefit of apitherapy against SARS‐CoV‐2.

In this direction, here, we present the numerous possibilities of apitherapy in combating COVID‐19 and highlight the importance of bee products as a promising source of therapeutic and prophylactic strategies against this emergent public health crisis.

Thursday, September 17, 2020

Apitherapy Clinic Opened in Canada to Treat Lyme Disease, Arthritis, Immune Disorders


Niagara man builds plan for new clinic on the backs of bees

Gord Howard

His father and grandfather were beekeepers back in Paraguay. Unger, who came to Canada in 1974, keeps about five million of them in hives at BY’s Honey Farm in Niagara-on-the-Lake.

He takes a bit of honey every day like a daily vitamin, and is a firm believer that bees and their byproducts can help help the body heal both physically and mentally.

Later this month he will open what he believes will be Canada’s first apitherapy clinic, using bee venom to ease the pain of people suffering a wide variety of ailments including Lyme disease, arthritis and an immune system weakened by chemotherapy...

Friday, September 11, 2020

Amy Schumer Has Lyme Disease — Why Do People Think Bees Can Help?


What is bee sting therapy?

Bee sting therapy is a form of apitherapy, which is an alternative treatment using products from honeybees. Along with bee sting venom, apitherapy can include honey, propolis, bee pollen, beeswax, and royal jelly.

"This strategy has been used in alternative medicine for more than 5,000 years," one study explains. "It consists of either indirect application, by extracting bee venom (BV) with an electric stimulus followed by its injection into the body or directly via bee stings."

To apply bee sting therapy directly, bees are held with a tweezer and placed onto a particular part of the body. After it stings, the bee is removed, but the stinger remains in the body for a short period of time.

This treatment was recently featured in the Netflix docuseries (Un)Well, so many people around the world were exposed to the idea of apitherapy to help manage symptoms of Lyme disease. In the sixth episode of the show, the founder of Heal Hive, Brooke Geahan, calls bee venom an antibacterial, antiviral, anti-parasitic, and an anti-inflammatory.

She then explains one property of bee venom, called melittin, which supposedly breaks into the cell walls containing the Lyme disease bacteria (B. burgdorferi) and causes them to burst...

Thursday, September 03, 2020

Korean Propolis Can Prevent H. pylori-Induced Gastric Damage (Ulcers)


Anti-inflammatory and anti-oxidative effect of Korean propolis on Helicobacter pylori-induced gastric damage in vitro


Journal of Microbiology (2020)

Helicobacter pylori, present in the stomach lining, is a Gramnegative bacterium that causes various gastrointestinal diseases, including gastritis and peptic ulcers. Propolis is a natural resinous substance collected from a variety of plants, and contains several natural bioactive substances. 

The aim of this study was to investigate the anti-inflammatory and antioxidative effects of Korean propolis on H. pylori-induced damage in the human adenocarcinoma gastric cell line. The propolis used in this study was obtained from the Korea Beekeeping Association in South Korea. The expression of pro-inflammatory interleukins (ILs), such as IL-8, IL-12, IL-1β, tumor necrosis factor alpha, cyclooxygenase-2, and inducible nitric oxide synthase, which was increased after H. pylori infection, significantly decreased in a dose-dependent manner upon pretreatment with Korean propolis, because of the suppression of mitogen-activated protein kinases and nuclear factor kB pathway. 

The anti-oxidative activity of propolis was assessed using the 2,2-diphenyl-1-picrylhydrazyl hydrate free radical assay. Korean propolis showed significant anti-oxidative effects via reactive oxygen species scavenging. In addition, pretreatment with Korean propolis upregulated the expression of anti-oxidant enzymes through Nrf2 signaling activation. These findings indicate that the use of Korean propolis, which has anti-inflammatory and anti-oxidative effects, can be promising for the prevention of H. pylori-induced gastric damage.

Wednesday, September 02, 2020

Honey Bee Venom Rapidly Kills Aggressive Breast Cancer Cells


Harry Perkins Institute of Medical Research study finds honeybee venom rapidly kills aggressive breast cancer cells


By Nicolas Perpitch

Venom from honeybees has been found to rapidly kill aggressive and hard-to-treat breast cancer cells, according to potentially groundbreaking new Australian research.

Key points:
  • The research was published in the journal Nature Precision Oncology
  • It found honeybee venom was effective in killing breast cancer cells
  • Researchers say the discovery is exciting but there is a long way to go
The study also found when the venom's main component was combined with existing chemotherapy drugs, it was extremely efficient at reducing tumour growth in mice...

Wednesday, August 26, 2020

Bee Venom Therapy Used to Treat Psoriasis


3 Interesting Types of Bee Venom Therapy

Bee stings typically cause painful swelling to the infected area due to venom. The venom or apitoxin has numerous compounds, enzymes, and amino acids that can be used to treat several health conditions.

Medical uses for bee venom have been traced back to the Ancient Egyptians, in Europe and Asia. The Greek physician Hippocrates used bee stings to treat arthritis and other joint pain. Other healers have used the venom for other conditions such as skin rashes.

Today, the venom enzymes have been found to have anti-inflammatory properties as well as ease pain and help heal wounds. There had also been several therapies involving immune system conditions such as eczema, rheumatoid arthritis, and even neurological diseases like Alzheimer's. Here are three types of been sting venom therapy:

For Psoriasis

A small study with 50 volunteers participated in an experiment for bee venom as therapy for skin lesions. Half of the patients with psoriasis had weekly injections of apitoxin while the rest received a placebo. After 3 months of bee sting venom therapy, patients had significantly reduced levels of inflammatory blood markers and psoriasis plaques.