Wednesday, August 05, 2020

Mexican University Researchers Recommend Propolis to Prevent COVID-19/Coronavirus Infection


UNAM scientists recommend taking propolis to prevent COVID – 19 – Very Interesting

Although there is still no medicine to treat COVID-19, UNAM recommends the use of propolis to keep the immune response in check.

The Faculty of Higher Studies Cuautitlán of the UNAM recommended the preventive use of this substance made by bees against COVID-19 and other viral diseases, such as seasonal influenza, thanks to the biological activity it has on viral, fungal and bacterial microorganisms.

Dr. Tonatiuh Cruz Sánchez, head of the Propolis Microbiological Bioprospecting Analysis Laboratory, explained that among the more than 300 chemical compounds observed over a decade of laboratory research, the phenols and flavonoids are responsible for their antimicrobial and probably antiviral action:

“Within the phenols is the phenethyl ester of caffeic acid (CAPE), which acts on polymerase, an enzyme capable of replicating an infectious microorganism, making it an excellent antibacterial. Also, flavonoids contain antioxidants such as pinocembrin and quercetin, which are attributed antiviral activity, “UNAM explained in a statement...

Tuesday, August 04, 2020

Slovenia Uses Sounds of Honey Bees as an Anti-Stress, Anti-Anxiety Relaxation Aid


How Slovenia uses the sound of bees to relax

By Martina Zoldos
30th July 2020

The country has a time-honoured tradition of using the sounds of bees buzzing to relax everyone from firefighters to school children, acting as an alleviant for anxiety and stress.

In our high-stress, modern society, there’s luckily no shortage of relaxation aids: bedtime story audio apps, phone-free offices, or ASMR, hypnotic YouTube videos of people whispering or crinkling wrapping paper into a microphone to help people drift to sleep.

But in Slovenia, there’s one relaxation technique that may actually shock some people, especially entomophobes: lying down in a room filled with cages of thousands of buzzing bees...

Wednesday, July 29, 2020

1st International Apitherapy Zoom Conference from 6 to 8 September 2020, Katowice, Poland


1st International Apitherapy Conference from 6 to 8 of September 2020 Katowice

From 6 to 8 of September, the 1st International Apitherapy Conference will be organized as ZOOM Conference under the auspices of the Medical University of Silesia, International Federation of Apitherapy, Romanian Apitherapy Society and German Apitherapy Society. Our goal is to present the latest developments of using bee products in medicine, pharmacy and cosmetology. The conference will be a forum for the exchange of experience in the field of apitherapy for representatives of scientific centers from Poland and abroad.

We would like to exchange scientific experience and present our achievements at the conference. Let’s meet on Zoom us.

Thursday, July 23, 2020

Australian, Malaysian, Brazilian Stingless Bee Honey Has Special Health Properties


Science sweetens native honey health claims

By University of Queensland

Science has validated Indigenous wisdom by identifying a rare, healthy sugar in native stingless bee honey that is not found in any other food.

University of Queensland organic chemist Associate Professor Mary Fletcher said Indigenous peoples had long known that native stingless bee honey had special health properties.

"We tested honey from two Australian native stingless bee species, two in Malaysia and one in Brazil and found that up to 85 per cent of their sugar is trehalulose, not maltose as previously thought," she said.

Dr. Fletcher said trehalulose was a rare sugar with a low glycaemic index (GI), and not found as a major component in any other foods.

"Traditionally it has been thought that stingless bee honey was good for diabetes and now we know why—having a lower GI means it takes longer for the sugar to be absorbed into the blood stream, so there is not a spike in glucose that you get from other sugars," Dr. Fletcher said...

Sunday, July 19, 2020

Mayan Propolis Shows Strong Anti-Inflammatory Properties

In vitro and in vivo anti-inflammatory properties of Mayan propolis

Propolis has been used traditionally for different human diseases and even recently as dental biomaterials because of its antibacterial, antimycotic, and anti-inflammatory properties. However, a proper correlation between in vitro and in vivo anti-inflammatory properties has not been clearly established.

...Chemical analysis showed pinocembrin, pinobanksin-3-O-acetate, and pinobanksin-3-O-propionate as the main components of propolis. Macrophage viability was high (106%) when propolis was used up to 50 µg/mL. ELISA studies showed a reduction in the expression of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) up to 145 pg/mL, 350 pg/mL, and 210pg/mL, respectively, while the anti-inflammatory cytokines (IL-10 and IL-4) were increased up to 833pg/mL and 446 pg/mL. Finally, edema was reduced on paw and ear mice by 9% and 22%, respectively.

Mayan propolis has strong in vitro anti-inflammatory properties without compromising macrophage
viability, resulting in a low-to-mild in vivo anti-inflammatory response.

Friday, July 17, 2020

Royal Jelly and Bee Pollen May Help Treat Menopausal Problems


Apitherapy for menopausal problems

Arch Gynecol Obstet. 2020 Jul 16

Purpose: Apitherapy, a method from the field of complementary and alternative medicine, claims that all health problems including menopausal problems can be cured using bee products, especially honey, bee-collected pollen, propolis, and royal jelly. This study was to investigate the recommendations of protagonists of holistic apitherapy and compare these to the current evidence.

Methods: Since holistic apitherapy is only promoted in books and apitherapeutical congresses, we identified books on the topic in English, French, and German language via bookseller platforms and the JUSTfind system of the Justus-Liebig-University Gießen, Germany, which comprises 337 databases from the EBSCO Discovery Service.

Results: Only 29.5% (n = 38) of the apitherapy books mentioned the topic of menopausal problems. Among these, there were 24 different recommendations. Royal jelly is the number one recommended therapy, followed by pollen, the combination of pollen and royal jelly, and propolis. All other recommendations are mentioned just once. The recommendation regarding royal jelly must be regarded as correct. Strictly speaking, evidence regarding bee-collected pollen is poor, since all studies on pollen did not investigate pollen directly, but pollen extracts and these pollens came from pollen that was anemophilous but not entomophilous.

Conclusion: Royal jelly and pollen could be interesting treatment options in cases of menopausal symptoms. In order to promote bee products for menopausal symptoms with a good conscience trials, comparing bee products against other options, such as selective serotonin reuptake inhibitors, C. racemosa extracts, and/or yoga should be initiated, since these methods have already proven their value.

Thursday, July 09, 2020

Greek Honey Has Antioxidant, Antiaging and Photoprotective Properties (Ageing, Aging, Seniors, Elderly, Skin Care, Health, Cosmetics)


Honey Extracts Exhibit Cytoprotective Properties Against UVB-Induced Photodamage in Human Experimental Skin Models

Antioxidants (Basel). 2020 Jun 30;9(7):E566

In the present study, we aimed to examine the antioxidant, antiaging and photoprotective properties of Greek honey samples of various botanical and geographical origin. Ethyl-acetate extracts were used and the and the total phenolic/flavonoid content and antioxidant capacity were evaluated. Honey extracts were then studied for their cytoprotective properties against UVB-induced photodamage using human immortalized keratinocytes (HaCaT) and/or reconstituted human skin tissue models. Specifically, the cytotoxicity, oxidative status, DNA damage and gene expression levels of specific matrix metalloproteinases (MMPs) were examined.

Overall, the treatment of HaCaT cells with honey extracts resulted in lower levels of DNA strand breaks and attenuated the decrease in cell viability following UVB exposure. Additionally, honey extracts significantly decreased the total protein carbonyl content of the irradiated cells, however, they had no significant effect on their total antioxidant status. Finally, the extracts alleviated the UVB-induced up-regulation of MMPs-3, -7 and -9 in a model of reconstituted skin tissue. In conclusion, honey extracts exhibited significant photoprotective and antiaging properties under UVB exposure conditions and thus could be further exploited as promising agents for developing novel and naturally-based, antiaging cosmeceutical products.

Friday, June 26, 2020

Colorado Woman Treats Lyme Disease with Bee Venom Acupuncture


Woman with Lyme disease reveals she stings herself with BEES on her spine 30 times a week to treat her symptoms - after spending $1,000 a month on other options that didn't work

  • Brittany Elliott, 27, from Denver, Colorado, opened up about bee venom therapy (BVT), or apitherapy, earlier this week in a viral TikTok video 
  • The footage, which shows herself stinging herself with live bees that she orders online, has been viewed more than 1.1 million times
  • Brittany said she was bitten by a tick at the age of seven but didn't develop symptoms until she moved into a home with toxic black mold when she was 22 
  • Lyme disease can typically be treated by several weeks of oral antibiotics, though some patients still report symptoms, including fatigue and joint pain
  • It took her years to finally get diagnosed with Lyme disease, but the treatments she was paying nearly $1,000 a month for weren't helping 
  • Brittany, who now stings herself with 10 bees, three times a week, believes two to three years of the treatment will rid her of symptoms 

Monday, June 15, 2020

Black Seed (Nigella Sativa) Honey as Supplementation Medium

Use of Black Seed (Nigella Sativa) Honey Bee to Improve Sheep Oocyte Maturation Medium 

Environ Sci Pollut Res Int. 2020 Jun 13

Sheep are important livestock and a source of milk, meat, and wool globally. The increasing demand for animal protein requires increased productivity in sheep. In vitro fertilization and maturation can improve sheep productivity.

The aims of this study were to evaluate the effects of honey bee addition as a supplementation medium on in vitro maturation improvement, gene expression of matured sheep oocytes, and determine the optimum concentration from honey bee for in vitro maturation of sheep oocytes. Cumulus oocyte complexes were obtained from the ovaries of slaughtered female sheep. Grade A and B oocytes were cultured for 24 h in medium without honey bee (control, G1) or medium supplemented with 5% (G2), 10% (G3), or 20% (G4) honey bee. Oocyte maturation rate, glutathione concentration, and the expression of candidate genes (GDF-9, BAX, Cyclin B, C-MOS, IGF1) were determined in the matured oocytes. The maturation rate of sheep oocyte was better in the presence of 5% and 10% honey bee; the mean number of oocytes in metaphase II stage was higher than that in G1 and G4 groups. Glutathione concentration was highest in G2 (10.93 ± 0.57).

In general, gene expression levels were similar in G2 and G3, which were greater that in G1 and G4.

In conclusion, the optimal concentration of black seeds honey bee that can be added to the maturation medium is 5% to obtain the highest mean MII and glutathione concentration values, and to improve gene expression in in vitro matured sheep oocytes.

Wednesday, June 10, 2020

Does bee venom apitherapy prevent coronavirus/COVID-19 infection?

The Sangai Express

...When the Global number of confirmed COVID-19 case exceeded 2 million on the 15th April, 2020, Physicians of Johns Hopkins Corona Virus Resource Centre participated in the prevention and control of Corona Virus in China. The report of the discovery reflected of the discovery of Cowpox and the eventual victory of humans over the disease follows as in Hubei province, the epicentre of COVID-19 in China.

The local beekeepers were surveyed from February 23 to March 8, including 723 in Wuhan, the outbreak epicentre of Hubei. None of these beekeepers developed symptoms associated with COVID-19 and their health was totally normal. After that they interviewed patients in five apitherapy clinics. These patients had received apitherapy from October 2019 to December 2019 and all the five bee apitherapists have the habit of self-apitherapy for their health care (Apitherapy means making use of bee Venom from the honeybee’s sting to treat or prevent certain disease). Without any protective measures, two of the five apitherapists were exposed to suspected COVID-19 cases and others were exposed to confirmed COVID-19 case, but none of them were infected eventually...

Monday, June 08, 2020

Royal Jelly May Help Treat Depression

Chronic Royal Jelly Administration Induced Antidepressant-Like Effects Through Increased Protein Expression of sirtuin1 and OXPHOS in the Amygdala of Mice

Curr Mol Pharmacol. 2020 Apr 24

Background: Major depressive disorder (MDD) is a common psychological disorder worldwide. However, one-third of patients with MDD are resistant to the present antidepressant medicine which regulates monoamine contents in the brain. Thus, another drug target is strongly required. Much evidence strongly suggests that sirtuin1, which is the key factor to regulate mitochondrial activity, may be implicated in MDD.

Objective: Since it is suggested that royal jelly (RJ) ameliorated depressive-like behavior and affected mitochondrial activity in mice, we hypothesized RJ could be an alternative medicine against MDD which acts via sirtuin1 signaling to improve mitochondrial activity.

Methods: In the present study, we applied a mouse model of MDD to investigate the effect of RJ on the depressive-like behavior and the sirtuin1 signaling on mitochondrial activity.

Results: Our results indicated that either the oral administration of RJ for 12 days or single intracerebroventricular (i.c.v.) injection decreased the duration of immobility in the tail suspension test, which suggested that RJ had an antidepressant-like effect. Moreover, sirtuin1 protein expression increased in mice following RJ treatment in the amygdala region, but not in the other brain regions. Similarly, the expressions of oxidative phosphorylation (OXPHOS) related proteins increased in the amygdala regions, but not in the hippocampal regions.

Conclusion: The increase of sirtuin1 and OXPHOS protein expression may at least in part contribute to the antidepressant-like effect of the RJ pathway, and RJ may have the potential to be a novel antidepressant drug.

Monday, May 25, 2020

Propolis Component May Help Block COVID-19/Coronavirus


Ashwagandha takes the lead to be the mother nature’s COVID-19 warrior: Study

They discovered that Withanone (Wi-N), a natural compound derived from Ashwagandha (Withania somnifera) and Caffeic Acid Phenethyl Ester (CAPE), an active ingredient of New Zealand propolis, have the potential to interact with and block the activity of Mpro. The team described that they have also searched for the capability to these bioactives to modulate the protein on the surface of human cells, to which the SARS-CoV-2 binds and allows its entry into our cell - the transmembrane protease serine 2 (TMPRSS2), and selected Withanone. The study is currently under review and expected to be published in a near future.

The team said that their findings may not only connect to save time and cost required for screening for anti-COVID-19 drugs, but may also offer some preventive and therapeutic value for the management of fatal COVID-19 pandemic, and hence warrant prioritized validation in the laboratory and clinical tests. They added that the drug development may take a while and in the current scenario, these natural resources (Ashwagandha and Propolis) may offer some preventive or even therapeutic value. However, although they are easily available and affordable, one has to be cautious about the content of bioactive ingredients. CAPE, while is a major component of propolis, its amount and stability are critical factors that could be managed by generating its complex with cyclodextrins. This has been earlier described by the DAILAB team. Withanone, on the other hand, varies with geography/parts/size of the Ashwagandha plant. So, in order to acquire or appreciate particular effects, we must use the right and quality-controlled resource/extracts.

Wednesday, May 20, 2020

Happy World Bee Day

Tualang Honey Supplementation as Cognitive Enhancer in Patients With Schizophrenia


Heliyon. 2020 May 12;6(5):e03948

Introduction: Schizophrenia is a chronic mental illness with clusters of symptoms, including cognitive impairment. This study aimed to explore the effect of Tualang Honey (TH) on cognitive domains, especially as it pertained to the verbal memory of schizophrenia patients.

Method: This was a cross-sectional study involved 80 individuals, diagnosed with schizophrenia. The Malay Version Auditory Verbal Learning Test (MVAVLT) was used. Data were analysed using SPSS 20.0 software. Intention to treat analysis was applied.

Result: A comparison of the total learning score at eight weeks between the two groups based on time effect and time-treatment interaction favoured TH group.

Conclusion: This study concludes that by supplementing schizophrenia patients with 8-week of TH did improve total learning performance across domains in the immediate memory among patients with schizophrenia.