Thursday, January 31, 2019

Manuka Honey Boosts Appearance of Skin, Better Sleep, Wound Healing - Soothes Sore Throats and Coughs, Supports a Healthy Gut


5 health benefits and uses of Manuka honey.

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Due to its antimicrobial activity, nutritional profile, and anti-inflammatory and humectant properties, Manuka honey has a variety of health and beauty benefits when eaten or used directly on the skin. Here are some of the most promising, research-backed reasons to consider adding Manuka honey to your daily diet and natural skin care regimen.

1. Boosts the appearance of skin

Manuka honey has been shown to have cosmetic benefits such as increasing the production of collagen (which in turn, increases skin elasticity), reducing dark spots, and acting as an anti-inflammatory, which may help calm inflammatory skin conditions like rosacea and acne. Due to its humectant properties (i.e., its ability to attract water to the surface of the skin as well as deliver hydration to the deeper layers), applying Manuka honey topically can also help skin retain moisture, making it a perfect addition to your beauty routine in cold, dry winter months.

Try it: For a simple face mask, spread a tablespoon of Manuka honey over your clean face (avoiding the eyes). Leave it on for 20 minutes, then rinse with warm water. Pat your face dry and apply your favorite moisturizer or facial oil. For additional skin-brightening, acne-fighting benefits, mix the Manuka honey with a pinch of turmeric before applying.

2. Lulls you to sleep faster

If you're struggling to catch some Zzzs, consider adding Manuka honey to your evening cup of herbal tea. Manuka honey contains high levels of tryptophan (also found in turkey, it's the same amino acid credited with making you drowsy after Thanksgiving dinner). Tryptophan, in turn, triggers the production of serotonin, which is a neurotransmitter that helps you relax and acts as a precursor to the production of melatonin, that all-important hormone that regulates sleep.

Try it: Add a teaspoon of Manuka honey to your evening cup of chamomile tea or golden milk.

3. Heals wounds and skin infections

What's more, Manuka honey is a powerful antibiotic—and one that could help treat skin infections otherwise considered untreatable, like methicillin-resistant Staphylococcus aureus (MRSA). There are currently no reports of microbial resistance to honey, and Manuka honey has specifically been shown to attack infections that have formed a biofilm—a stage that was once thought to render infections untreatable. In one study, the application of honey to diabetic foot ulcers was found to heal 43.3 percent of ulcers completely.

Try it: For small, manageable cuts and scrapes, add a dab of Manuka honey directly to the skin before attaching your bandage. For larger wounds, always consult a doctor.

4. Soothes sore throats and coughs

Manuka honey is commonly associated with healing a sore throat. Not only do its antibacterial, antiviral, and antifungal properties create the perfect trifecta for treatment, but Manuka's thick, viscous texture coats and soothes the throat, helping destroy the harmful bacteria in its path. Manuka honey can help prevent coughs from keeping you up at night, too. One study found sleep conditions improved for both children and adults suffering from upper respiratory issues when they took honey before bed.

Try it: Simply swallow a tablespoon of Manuka honey straight-up and allow it to coat your throat. Alternatively (or additionally), you can add Manuka honey to ginger tea for extra anti-inflammatory benefits.

5. Supports a healthy gut

Research suggests that Manuka honey has the ability to help with various digestive disorders. In animal studies, the high antioxidant content of Manuka has been effective in treating gastric ulcers and inflammatory bowel disease. Due to its antimicrobial properties, Manuka may also help fight pathogens in the gut. In two separate lab studies, both Clostridium difficile (C. diff) and Helicobacter pylori (H. pylori) were susceptible to the antibacterial properties in Manuka honey.

Wednesday, January 30, 2019

Bee Venom Helps Treat Arthritis, Lupus, Sciatica


Medical value of Bee Venom in the “Treatment of Arthritis”

January 27, 2019 

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Medical value of Bee Venom: Species of honey bee are almost 20,000 in all over the world and closely relative to ants, wasps and hornets. All these species fall in one genus that is “Apis” and almost 44 species are known under it.

In Pakistan, there are four species of honey bee and these are Apis dorsta, Apis cerana, Apis melifera and Apis floera and following are the products of honey bee “honey bee, bee wax, pollen, royal jelly, and propolis and bee venom.

So, Bee Venom is one of the major product of honey bee which has been used in the field of medicine and my focus is on the use of “bee venom” of honey bee especially in the treatment of arthritis. Arthritis is a joint pain or joint disease.

First time, it was reported date back as far as 4500 BC, but it is most common disease of pre-historic people. Evidences suggest that it has been found throughout history e.g., from Egyptian mummies in 2590 BC, and then in other countries like Italy, Austria, China, Korea and Pakistan.

There are found more than 100 types of arthritis. Almost all ages and sexes of people are effected by arthritis and this disease is a cause major of disability in Pakistan. But most commonly, women are affected by arthritis frequently as they become older.

Symptoms of Arthritis:

The symptoms of a common arthritis are such as swelling, stiffness, pain and decrease in mobility range. In the beginning, it may be mild then moderate and later it becomes severe. Then in severe conditions chronic pain causing this disease is turned into inability of the patient to perform daily work.

A person which has been affected by this disease, for patients it is difficult to walk or climb stairs. It may cause permanent changes in joints. It may also affect the other body organs like lungs, heart, eyes, kidney and skin as well as the joints. There are different treatments available such as resting, weight control, applying ice or heat, exercise, joint replacement surgery and some medicines like Ibuprofen and paracetamol etc.

Benefits of Bee Venom:

The use of honey and its products in human treatment is not a new at all; it has been practiced in thousands of years ago. Due to its healing properties, the word “Honey” is use in many verses at many times in Quran. The term apitherapy is use in medical field which means the use of honey bee products for medicinal or medical purposes like propolis, royal jelly, pollen, bee venom, bee wax and raw honey.

However, the bee venom therapy is a live bee stings which is used in many treatments for various diseases like as arthritis (all types of arthritis like chronic arthritis, sub-chronic arthritis, poly arthritis etc)i.e; sciatica, lupus, rheumatoid arthritis, multiple sclerosis (MS), low back pain and tennis elbow...

Tuesday, January 29, 2019

Beeswax Coating Helps Maintain Fruit Quality


Effect of beeswax and chitosan treatments on quality and shelf life of selected mango (Mangifera indica L.) cultivars

Heliyon. 2019 Jan 9;5(1):e01116 

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Mango is one of the most economically important fruit facing greater problems in storage and transportation to long distance market because of its perishable nature. Evidence suggested that application of edible coatings is a key step to reduce loss of perishable commodities. In line with this, Beeswax and chitosan at different concentrations (0.5%, 1.5% and 2%), and two mango varieties (Apple and Tommy Atkins) were evaluated using completely randomized design (CRD) in three replications. Application of beeswax and chitosan at (2%) significantly reduced physiological weight loss (%), total soluble solid (°Brix), titratable acidity (%), pH, disease incidence (%), disease index (%), maintained Firmness (N) and prolonged shelf-life of fruits compared with untreated control. It was concluded that edible coatings used in the present study have a good potential in maintaining the fruit quality and beeswax at 2% being the most effective treatment on all parameters tested.

Monday, January 28, 2019

Mauritian Eucalyptus Honey Shows Antibacterial, Antioxidant and Anti-Cancer Activity

Pharmacological activities, chemical profile, and physico-chemical properties of raw and commercial honey

Biocatalysis and Agricultural Biotechnology
Available online 26 January 2019

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

This study was designed to evaluate and correlate the pharmacological, phytochemical, and physicochemical properties of raw unifloral Mauritian eucalyptus honey (EH) and a commercially available honey (CH).

The pharmacological activity was evaluated in terms of antibacterial, antioxidant (nitric oxide scavenging), antielastase, antityrosinase, antimelanogenic, and anticancer activity (MCF-7 and HeLa cell toxicity). The presence of phytochemicals including alkaloids, flavonoids, saponins, phenols, anthraquinones, and steroids were determined along with the total phenolic (TPC), total flavonoid (TFC), and tannin content (TC). Physicochemical properties including pH, colour, total soluble solids, and density were also investigated.

The results showed that EH displayed greater antibacterial, antioxidant, and anticancer activity against the MCF-7 cell line compared to CH, which showed higher extracellular antimelanogenic activity. MH (IC50 = 532.75 μg/ml) displayed significantly greater scavenging activity than CH (IC50 = 647.6 μg/ml).

To conclude, honey may be potentially exploited as complementary and alternative therapies for the management of infectious and chronic diseases.

Sunday, January 27, 2019

Red, Poplar Propolis May Help Heal Wounds

Natural rubber latex membranes incorporated with three different types of propolis: Physical-chemistry and antimicrobial behaviours

Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:576-582

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Natural Rubber Latex (NRL) is a biocompatible material with demonstrated capacity to induce vascularisation and tissue regeneration. Propolis is a complex resinous product prepared by Apis mellifera with the aim of protecting beehives against infectious microorganisms. It is flora-dependent and its antimicrobial activity can vary according to its geographical origin.

This study compares the incorporation of three different types of propolis into an NRL membrane aiming at optimal controlled release of propolis potential antimicrobial compounds towards Candida albicans whilst keeping NRL mechanical characteristics desirable for wound healing bandage purposes.

The propolis samples were classified as red, green and poplar propolis according to their chemical composition determined by ultra-high performance liquid chromatography coupled in series with both UV spectrophotometry and high-resolution mass spectrometry. The Minimum Inhibitory Concentrations (MIC) towards C. albicans were determined before their incorporation into NRL membranes. The release of NRL-propolis components in Simulated Body Fluid (SBF) was monitored by UV-Vis spectroscopy. The antimicrobial activity and the effects of the materials released on mouse fibroblasts were assessed. FTIR analyses were carried out in order to verify the formation of new chemical bonds that might prevent the release of propolis components from the NRL membrane.

The mechanical characteristics of the NRL membranes remained adequate after the incorporation of the three types of propolis investigated whilst allowing the release of the red, and poplar propolis most active compounds against C. albicans. At 30 and 50% the released materials (eluates) from the NRL membranes incorporated with red and poplar propolis types were not toxic to fibroblast cells.

These results suggest that red and poplar propolis can be incorporated into NRL membranes for the preparation of wound healing dressing.

Saturday, January 26, 2019

Antimicrobial Activity of Latin American Stingless Bees

Phylogenetic analyses of antibiotic-producing Streptomyces sp. isolates obtained from the stingless-bee Tetragonisca angustula (Apidae: Meliponini)

Microbiology. 2019 Jan 24

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Many insects have been associated with actinobacteria in protective symbiosis where antimicrobial metabolites inhibit host pathogens. However, the microbiota of neotropical insects such as the stingless-bee Tetragonica angustula is poorly explored.

T. angustula is a meliponid bee widely distributed in Latin America, its honey is traditionally exploited because of its ethno-pharmacological properties and its antimicrobial activity has been demonstrated. Also, the well-structured nest of this species allows exploration of the microbiota of its different components.

Even though Streptomyces spp. have been cultured from stingless-bees, little is known about their role in this insect-microbe relationship.

In this study, we examined the association between culturable actinobacteria and T. angustula, and evaluated the isolates' potential as antimicrobial producers. We isolated 51 actinobacteria from adult bees and different substrates of the hive of T. angustula (pollen and honey storage, garbage pellets and cerumen).

We then performed a 16S rRNA phylogenetic analysis that clusters the bacteria to previously described lineages of host-associated Streptomyces. In addition, all the isolates were classified according to their antibacterial activity against human pathogens, measured by a growth inhibition test based on diffusion in agar. More than 50 % of our isolates exhibit antimicrobial activity, mainly to Gram-positive bacteria and fungi and only two against Gram-negative bacteria.

Additionally, we obtained electron micrographs of adult bees with what appears to be patches of hyphae with Streptomyces-like cell morphology on their body surface.

Our results suggest that T. angustula possibly uptakes and transfers actinobacteria from the environment, acting as vectors for these potentially beneficial organisms.

This research provides new insights regarding the microbiota associated with T. angustula and justify future studies exploring the full diversity of the microbial community associated with the hive and the possible exchange of microbes with the crops they pollinate.

Thursday, January 24, 2019

Chinese Propolis Extract May Help Treat Diabetic Retinopathy

Ethanol Extract of Chinese Propolis Attenuates Early Diabetic Retinopathy by Protecting the Blood-Retinal Barrier in Streptozotocin-Induced Diabetic Rats

J Food Sci. 2019 Jan 23. doi: 10.1111/1750-3841.14435

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Propolis has been shown to reduce the level of blood glucose and suppress the histopathological changes in diabetics. However, it still remains unknown if propolis has a similar effect on diabetic retinopathy (DR).

Our study aimed to evaluate the effect of the ethanol extract of Chinese propolis (EECP) on early DR in streptozotocin (STZ)-induced diabetic rats. EECP was given to diabetic rats by oral intubation for 12 weeks. The concentrations of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), malondialdehyde (MDA), reactive oxygen species (ROS), and reactive nitrogen species (RNS) were measured. Pathological examinations, including hematoxylin and eosin (HE) staining, transmission electron microscopy (TEM), and immunofluorescence, were also conducted to provide further evidence of EECP's effect on early DR. EECP was able to attenuate diabetes via directly decreasing the levels of FBG and HbA1c, which also resulted in the reduction of MDA, ROS, and RNS. Furthermore, EECP could protect against the damages of photoreceptor cells, as well as retinal thickening. And the inhibition of blood-retinal barrier (BRB) leakage was also observed in EECP-treated diabetic rats, along with the inhibition the loss of tight junction proteins (occludin, ZO-1).

These results suggest that EECP has an ameliorating effect on early DR by inhibition of blood-retinal barrier breakdown. PRACTICAL APPLICATION: This study sheds light on the protective effect of the ethanol extract of Chinese propolis on early diabetic retinopathy and the molecular actions underlying the inhibition of blood-retinal barrier breakdown.

Our study suggests that ethanol extract of Chinese propolis can be considered as a potential therapeutic agent in the treatment of early diabetic retinopathy.

Wednesday, January 23, 2019

Honey Component May Help Prevent, Treat Heart Diseases

The cardiovascular protective effects of chrysin: A narrative review on experimental researches

Cardiovasc Hematol Agents Med Chem. 2019 Jan 14

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Chrysin is one of the flavonoids fruits, vegetables, and plant especially found in honey, it has been indicated that its cardiovascular protective effect is due to its antioxidative effects and anti-inflammatory activities.

Chrysin exerts an antioxidant effect by enhancing the antioxidant system, suppressing pro-oxidant enzymes, scavenging free radicals and chelating redox active transition-metal ions. Chrysin decreases lipid synthesis and also increases its metabolism, thereby ameliorating blood lipid profile. Chrysin modulates vascular function by increasing the bioavailability of endothelial nitric oxide.

Chrysin inhibits the development of atherosclerosis by decreasing vascular inflammation. The anti-inflammatory effects of chrysin may relate to its inhibitory effect on the nuclear transcriptional factor-kB signaling pathway. It also prevents vascular smooth muscle cells proliferation and thrombogenesis.

Altogether, chrysin may be effective as a natural agent for the prevention and treatment of cardiovascular diseases; however, several clinical trial studies should be done to confirm its protective effects on humans.

Tuesday, January 22, 2019

Propolis Component May Help Protect Kidneys of People with Diabetes


Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy

Nutrients. 2019 Jan 9;11(1). pii: E127

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Advanced glycation end products (AGE) play a causative role in the development of aberrant phenotypes of intraglomerular mesangial cells, contributing to acute/chronic glomerulonephritis.

The aim of this study was to explore mechanistic effects of the flavonoid chrysin present in bee propolis and herbs on actin dynamics, focal adhesion, and the migration of AGE-exposed mesangial cells. The in vitro study cultured human mesangial cells exposed to 33 mM glucose and 100 μg/mL AGE-bovine serum albumin (AGE-BSA) for up to 5 days in the absence and presence of 1⁻20 μM chrysin.

The in vivo study employed db/db mice orally administrated for 10 weeks with 10 mg/kg chrysin. The presence of ≥10 μM chrysin attenuated mesangial F-actin induction and bundle formation enhanced by AGE. Chrysin reduced the mesangial induction of α-smooth muscle actin (α-SMA) by glucose, and diminished the tissue α-SMA level in diabetic kidneys, indicating its blockade of mesangial proliferation.

The treatment of chrysin inhibited the activation of vinculin and paxillin and the induction of cortactin, ARP2/3, fascin-1, and Ena/VASP-like protein in AGE-exposed mesangial cells. Oral administration of chrysin diminished tissue levels of cortactin and fascin-1 elevated in diabetic mouse kidneys. Mesangial cell motility was enhanced by AGE, which was markedly attenuated by adding chrysin to cells.

On the other hand, chrysin dampened the induction of autophagy-related genes of beclin-1, LC3 I/II, Atg3, and Atg7 in mesangial cells exposed to AGE and in diabetic kidneys. Furthermore, chrysin reduced the mTOR activation in AGE-exposed mesangial cells and diabetic kidneys.

The induction of mesangial F-actin, cortactin, and fascin-1 by AGE was deterred by the inhibition of autophagy and mTOR.

Thus, chrysin may encumber diabetes-associated formation of actin bundling and focal adhesion and mesangial cell motility through disturbing autophagy and mTOR pathway.

Monday, January 21, 2019

Health Benefits of Honey, Bee Pollen

Healthy living with bees: Investigating the antioxidant properties of honey and pollen

Ezine

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Bees rather handily produce a wide range of health-promoting substances, including honey, beeswax, propolis and royal jelly. Even the pollen that bees collect along with the nectar has health benefits. Many of these benefits derive from the fact that these substances are rich in antioxidants such as flavonoids and other polyphenols, which soak up harmful reactive oxygen species (ROS).

Now, chemists from Portugal and Algeria, led by Ana Oliveira-Brett from the University of Coimbra, have come up with a quick and easy analytical process, comprising several comparatively simple analytical techniques, for investigating in detail the antioxidant properties of bee products...

Honey and pollen

They first tested this analytical process on 10 samples of honey from Greece, Portugal, Algeria and Romania, and two samples of pollen from Portugal and Romania. This involved first extracting the polyphenols from the honey and pollen samples by immersing them in a mixture of water, ethanol and methanol, and then exposing them to ultrasound.

DP voltammetry and the DPPH spectrophotometric assay revealed that the extracted polyphenols possessed high levels of antioxidant activity, with the results from both techniques tending to agree with each other.  HPLC-ED revealed that all the honey and pollen samples contained a similar range of polyphenols, including several anthocyanidins and flavanols, although they differed in their concentrations.

These results also indicated that the relationship between polyphenol concentration and antioxidant activity isn’t entirely straightforward. Among the honeys, a honey from Portugal had the highest polyphenol concentrations, even though a Greek honey had the highest antioxidant activity.

Finally, the chemists conducted the gel electrophoresis step with four of the honey samples and one of the pollen samples. This showed that, irrespective of their antioxidant activities or polyphenol concentrations, all the samples helped to protect the DNA from damage by soaking up the ROS.

These findings not only confirm the health benefits of honey and pollen, but also raise the possibility of using this analytical process to explore the health benefits of the various other bee products as well.

Sunday, January 20, 2019

Royal Jelly May Help Treat Alzheimer's Disease


Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells

Sci Rep. 2019 Jan 17;9(1):168

BUY Concentrated Propolis in Veggie Capsules  

BUY 3-Piece (2 Fountain Pens, Rollerball) Gift Set 

Royal jelly (RJ) is a type of natural health product with a long history of use. Royal jelly peptides (RJPs) obtained from RJ have numerous bioactivities.

To study the neuroprotective effect of RJPs, major royal jelly proteins were digested into crude RJPs and subsequently purified by RP-HPLC. Purified RJP fractions were evaluated in N2a/APP695swe cells. Our results indicated that purified royal jelly peptides (RJPs) (1-9 μg/mL) could inhibit external beta-amyloid 40 (Aβ1-40) and beta-amyloid 42 (Aβ1-42) production through the down-regulation of β-secretase (BACE1) in N2a/APP695 cells. The modulation of BACE1 may be related to histone acetylation modification.

Our results demonstrated a neuroprotective function of RJPs, which indicates that RJPs may serve as potential β-secretase inhibitors in ameliorating Aβ-related pathology in Alzheimer's Disease.

Saturday, January 19, 2019

Propolis Spray Boosts Immunity, Treats Children's Sore Throats

This Natural Throat Spray Keeps Kids Healthy And Sniffle-Free

By Patch Deals, Patch National Staff | Jan 18, 2019

BUY Concentrated Propolis in Veggie Capsules  

We've reached that time of year again where it seems like no amount of hand-washing or cough-covering is going to keep the kids from getting sick. Germs are everywhere, but we've finally found a natural, effective product to boost our little ones' immune systems and help fight off sore throats and sniffles: It's a propolis spray from Beekeeper's Naturals, and we'll never face another winter without it.

Propolis is a mix of bee saliva and beeswax and other natural goodness, and it basically works as a glue to seal their hives and hold everything together. It's nature's ultimate protector, and it's been used for centuries by humans for immune support. This Beekeeper's Naturals throat spray contains bee propolis (95 percent extract) and just a little bit of buckwheat honey for a natural sweet flavor. Kids love the taste, and parents love that it's a great source of antioxidants...

Friday, January 18, 2019

Citrus Blossom Honey Boosts Activity of Gold Nanoparticles Against Super Bugs (MRSA, VRSA)

MIC and MBC of Honey and Gold Nanoparticles against methicillin-resistant (MRSA) and vancomycin-resistant (VRSA) coagulase-positive S. aureus isolated from contagious bovine clinical mastitis

J Genet Eng Biotechnol. 2017 Jun;15(1):219-230

BUY Concentrated Propolis in Veggie Capsules 

Staphylococcus aureus is one of the major causative agents of the bovine clinical mastitis. This study aimed to isolate and identify S. aureus from cases of bovine clinical mastitis followed by phenotypic detection of MRSA and VRSA.

The genotypic detection of MRSA was done through PCR detection of the resistance mecA gene. Furthermore, this study aimed to investigate the in vitro MIC and MBC of the Dodonaea angustifolia plant extract, Honey, and AuNPs against the clinically isolated MRSA and VRSA. Of 93 mastitis milk samples examined, 54 (58.1%) S. aureus were isolated and identified {CP S. aureus = 46 (85.2%) and CN S. aureus = 8 (14.8%)}. The whole MRSA, VRSA, MSSA, and VSSA detected were 19 (35.2%), 7 (13%), 35 (65%), and 47 (87%) respectively. The mean counts of S. aureus were between 8.6 × 104 ± 3.5 × 105 CFU/ml.

The oxacillin and vancomycin MICs against MRSA and VRSA respectively, were >256 µg/ml. AuNPs sized 30 nm produce observable in vitro anti-MRSA and anti-VRSA activities. Imtenan® citrus blossom honey has also antibacterial activities against MRSA and VRSA with general MBC and MIC range values were observed at a concentration of 0.625, 1.25, 2.5, and 5 (%v/v).

In the present study, the most significant result obtained when AuNPs was mixed with Imtenan® citrus blossom honey (1:1 = v:v) with the best MBC was observed at the concentration of 0.56 × 109:0.3 (NP/ml: honey %v/v).

Thursday, January 17, 2019

Royal Jelly May Help Treat Diabetes

Complementary Therapies in Medicine
Volume 43, April 2019, Pages 20-27

BUY Concentrated Propolis in Veggie Capsules    

Highlights

• Royal jelly may help improve glycemic status and oxidative stress in diabetes mellitus.
• Royal jelly effects on lipid profile are contradictory.
• Studies on the Royal jelly effects on inflammatory markers in diabetes mellitus were not enough.
• More studies are required to determine the exact mechanisms of Royal jelly in diabetes mellitus.

Diabetes mellitus is one of the most common endocrine disorders in the world. This systematic review was conducted with focus on the current knowledge on the effect of royal jelly on metabolic variables in diabetes mellitus. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched from inception until June 2018. All clinical trials and animal studies that evaluated the effects of royal jelly on diabetes mellitus, and were published in English-language journals were eligible. Studies that provided insufficient outcomes were excluded. Out of 522 articles found in the search, only twelve articles were eligible for analysis. Seven studies showed a significant reduction in FBS, and one reported HbA1c decrease following royal jelly supplementation. Although royal jelly supplementation resulted in significant reductions in HOM A-I R in three studies, the findings on insulin levels were controversial. In addition, royal jelly substantially improved serum levels of triglycerides, cholesterol, HDL, LDL, VLDL and Apo-A1 in diabetes mellitus. In addition, royal jelly resulted in a decrease oxidative stress indicators and increase antioxidant enzymes levels. In conclusion, royal jelly could improve glycemic status, lipid profiles and oxidative stress in diabetes mellitus. However, exploring the underlying mechanisms warrants further studies.

Wednesday, January 16, 2019

Stingless Bee Honey May Help Treat Obesity


Supplementation of Stingless Bee Honey from Heterotrigona itama Improves Antiobesity Parameters in High-Fat Diet Induced Obese Rat Model

Evid Based Complement Alternat Med. 2018 Nov 21;2018:6371582

BUY Concentrated Propolis in Veggie Capsules   

Heterotrigona itama is a common stingless bee species found in Southeast Asia. Studies on the health benefits of its honey are limited in comparison with other stingless bee species.

This study examines the antiobesity benefits found in stingless bee honey (SBH) from H. itama. The parameters used to measure the benefits were weight change, morphological structures, and biochemical characteristics. The research was conducted by using rats that were given a high-fat diet (HFD). In total 48 male Sprague Dawley (SD) rats were given a formulated HFD to increase the levels of obesity, the HFD was administered with a value of 0.68 g/cm2.

The duration of the treatment was six weeks, and the results show that the induction obesity using the HFD was successful. Following this, the rats were then treated with SBH (at dosages of 1000 mg/kg, 750 mg/kg or 500 mg/kg), with orlistat or with a placebo. Compared with typical obesity treatment methods, the one that used the three dosages of SBH showed a higher reduction in body mass index (BMI), percentage of body weight gain, adiposity index, and relative organ weight (ROW). The levels of liver enzymes (ALT, AST, and ALP) were also significantly lower in SBH-treated groups. The levels of triglycerides and LDL-cholesterol were significantly lower, while the level of HDL-cholesterol was significantly higher in comparison with the control obese group.

In terms of morphological structures, the number of adipocyte cells was reduced, and the hepatocytes found in the liver were less prone to rupturing when treated with SBH.

In conclusion, the administration of SBH led to an improvement in indicators associated with obesity reduction. SBH also possesses a hepatoprotective potential which can reduce the health risks related to obesity.