Saturday, December 04, 2010
Mem Inst Oswaldo Cruz, 2010 Nov;105(7):908-13
Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1).
When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01).
Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05)…
The data presented in this paper clearly demonstrate the adjuvant activity of phenolic compounds obtained from Brazilian green propolis when co-administered in mice with an inactivated vaccine against SuHV-1. This adjuvant activity was evident in the increase in both cellular and humoral immune responses. Prenylated phenolic compounds such as Artepillin C that act at the cell signaling level are likely the main substances with adjuvant activity.