Systemic Propolis Stimulates New Bone Formation at the Expanded
Suture
Angle Orthod, 2012 Aug 20
Objective: To investigate the effects of systemically given
propolis on the expanded premaxillary suture in a rat study model.
Materials and Methods: The 24 rats were randomly divided
into three groups-only expansion (OE), expansion plus propolis (PRO), and
nonexpansion (control) groups. After the 5-day expansion period was completed,
the OE and PRO groups underwent 12 days of mechanical retention. At the end of
this period, the animals were euthanatized and their pre-maxillae were
dissected and fixed. Histomorphometric examination was performed to determine
the number of osteoclasts, osteoblasts, and capillaries as well as the
intensity of inflammatory cells and amount of new bone formation.
Results: Statistical analysis showed that the intensities of
inflammatory cells, number of osteoblasts, and amount of new bone formation
were greater in the PRO group than in the other groups. The PRO group also had
more osteoclasts and new capillaries.
Conclusion: Systemic use of propolis may hasten new bone
formation at the expanded suture in rats.
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