Royal jelly attenuates azathioprine induced toxicity in rats
Environ Toxicol Pharmacol, 2013 Dec 31;37(1):431-437
In the present study, we investigated the potential
protective effects of royal jelly against azathioprine-induced toxicity in rat.
Intraperitoneal administration of azathioprine (50mg/kgB.W.) induced a
significant decrease in RBCs count, Hb concentration, PCV%, WBCs count,
differential count and platelet count, hepatic antioxidant enzymes (reduced
glutathione and glutathione s-transferase) and increase of serum transaminases
(alanine aminotransferase and aspartate aminotransferase enzymes) activities,
alkaline phosphatase and malondialdehyde formation. Azathioprine induced
hepatotoxicity was reflected by marked pathological changes in the liver.
Oral
administration of royal jelly (200mg/kgB.W.) was efficient in counteracting
azathioprine toxicity whereas it altered the anemic condition, leucopenia and
thrombocytopenia induced by azathioprine. Furthermore, royal jelly exerted
significant protection against liver damage induced by azathioprine through
reduction of the elevated activities of serum hepatic enzymes. Moreover, royal
jelly blocked azathioprine-induced lipid peroxidation through decreasing the
malondialdehyde formation. In conclusion, royal jelly possesses a capability to
attenuate azathioprine-induced toxicity.
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