Antimicrobial, antioxidant and cytotoxic activities of
propolis from Melipona orbignyi (Hymenoptera, Apidae)
Food Chem Toxicol, 2014 Jan 9. pii: S0278-6915(14)00011-8
Propolis from stingless bees is well known for its biologic
properties; however, few studies have demonstrated these effects. Therefore,
this study aimed to investigate the chemical composition and antimicrobial,
antioxidant and cytotoxic activities of propolis from the stingless bee
Melipona orbignyi, found in Mato Grosso do Sul, Brazil. The chemical
composition of the ethanol extract of propolis (EEP) indicated the presence of
aromatic acids, phenolic compounds, alcohols, terpenes and sugars. The EEP was
active against the bacterium Staphylococcus aureus and the fungus Candida
albicans. The EEP showed antioxidant activity by scavenging free radicals and
inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated
with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and
primarily necrotic death in K562 erythroleukemia cells. Taken together, these
results indicate that propolis from M. orbignyi has therapeutic potential for
the treatment and/or prevention of diseases related to microorganism activity,
oxidative stress and tumor cell proliferation.
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