Royal jelly protects from taxol-induced testicular damages
via improvement of antioxidant status and up-regulation of E2f1
Syst Biol Reprod Med, 2013 Dec 31
This study was carried out to evaluate the protective
effects of royal jelly (RJ) on taxol (TXL)-induced damage of the testis. Wistar
rats were divided into control and test groups. The test group was divided into
five subgroups; the first four groups along with TXL administration (7.5 mg/kg
body weight (bw), weekly), received various doses of RJ (0, 50, 100, and
150 mg/kg bw). The last group received only RJ at 100 mg/kg. Royal jelly
lowered the TXL-induced malondialdehyde and nitric oxide levels and enhanced
the total thiol molecules in the testis. Remarkably RJ reduced the TXL-induced
pathological injuries such as cellular shrinkage and seminiferous tubule
depletion. Taxol-reduced sperm viability (27.5 ± 2.98 % vs. 85.0 ± 8.6% in the
control group) was recovered by RJ administration as 80.5 ± 10.6% of the sperm
were found alive in the group of animals which received 150 mg/kg RJ. The
TXL-exposed and TXL plus RJ-administered animals showed a significant
up-regulation of transcription factor E2f1 mRNA.
Our data suggest that the TXL-induced histopathological and
biochemical alterations could be protected by the administration of RJ. The RJ
protective effects might be attributed to its antioxidant capacity and its
capability in the regulation of E2f1 expression.
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